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White and gray matter development in human fetal, newborn and pediatric brains.

White and gray matter development in human fetal, newborn and pediatric brains. Research Abstract Details 

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  • White and gray matter development in human fetal, newborn and pediatric brains. Abstract Text:

    hao huangHao Huang,jiangyang zhangJiangyang Zhang,setsu wakanaSetsu Wakana,weihong zhangWeihong Zhang,tianbo renTianbo Ren,linda j richardsLinda J Richards,paul yarowskyPaul Yarowsky,pamela donohuePamela Donohue,ernest grahamErnest Graham,peter c m van zijlPeter C M van Zijl,susumu moriSusumu Mori,

    Brain anatomy is characterized by dramatic growth from the end of the second trimester through the neonatal stage. The characterization of normal axonal growth of the white matter tracts has not been well-documented to date and could provide important clues to understanding the extensive inhomogeneity of white matter injuries in cerebral palsy (CP) patients. However, anatomical studies of human brain development during this period are surprisingly scarce and histology-based atlases have become available only recently. Diffusion tensor magnetic resonance imaging (DTMRI) can reveal detailed anatomy of white matter. We acquired diffusion tensor images (DTI) of postmortem fetal brain samples and in vivo neonates and children. Neural structures were annotated in two-dimensional (2D) slices, segmented, measured, and reconstructed three-dimensionally (3D). The growth status of various white matter tracts was evaluated on cross-sections at 19-20 gestational weeks, and compared with 0-month-old neonates and 5- to 6-year-old children. Limbic, commissural, association, and projection white matter tracts and gray matter structures were illustrated in 3D and quantitatively characterized to assess their dynamic changes. The overall pattern of the time courses for the development of different white matter is that limbic fibers develop first and association fibers last and commissural and projection fibers are forming from anterior to posterior part of the brain. The resultant DTMRI-based 3D human brain data will be a valuable resource for human brain developmental study and will provide reference standards for diagnostic radiology of premature newborns.

    White and gray matter development in human fetal, newborn and pediatric brains. Publishing Authors By Initials

    h huangH Huang,j zhangJ Zhang,s wakanaS Wakana,w zhangW Zhang,t renT Ren,lj richardsLJ Richards,p yarowskyP Yarowsky,p donohueP Donohue,e grahamE Graham,pc van zijlPC van Zijl,s moriS Mori,

    For similar abstracts research abstracts see: abstracts research

    PUBMED ID PMID:

    MEDLINE DATE:

    White and gray matter development in human fetal, newborn and pediatric brains. Journal Published:

    PUBLICATION TYPE: Research Support, N.I.H., Extr

    Journal: NeuroImage

    VOLUME: 33

    Page Numbers: 27-38

    Journal Abbreviation:

    ISSN: 1053-8119

    DAY: 14

    MONTH: 08

    YEAR: 2006

    White and gray matter development in human fetal, newborn and pediatric brains. Information

    Number of References:

    LANGUAGE: eng

    NlmUniqueID: 9215515

    White and gray matter development in human fetal, newborn and pediatric brains. Keywords Mesh Terms:

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    Grant and Affiliation Information for White and gray matter development in human fetal, newborn and pediatric brains.

    AFFILIATION: Department of Radiology, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA.

    Country: United States

    United States Research PublicationUnited States Research Publication

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    MEDLINETA: Neuroimage

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