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Vulnerable window for conduction block in a one-dimensional cable of cardiac cells, 2: multiple extrasystoles.

Vulnerable window for conduction block in a one-dimensional cable of cardiac cells, 2: multiple extrasystoles. Research Abstract Details 

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  • Vulnerable window for conduction block in a one-dimensional cable of cardiac cells, 2: multiple extrasystoles. Abstract Text:

    zhilin quZhilin Qu,alan garfinkelAlan Garfinkel,james n weissJames N Weiss,

    Unidirectional conduction block of premature extrasystoles can lead to initiation of cardiac reentry, causing lethal arrhythmias including ventricular fibrillation. Multiple extrasystoles are often more effective at inducing unidirectional conduction block and reentry than a single extrasystole. Since the substrate for conduction block is spatial dispersion of refractoriness, in this study we investigate how the first extrasystole modulates this dispersion to influence the "vulnerable window" for conduction block by subsequent extrasystoles, particularly in relation to action potential duration restitution and conduction velocity restitution properties. Using a kinematic model to represent wavefront-waveback interactions and simulations with the Luo-Rudy model in a one-dimensional cable of cardiac cells, we show that in homogeneous tissue, a premature extrasystole can create a large dispersion of refractoriness leading to conduction block of a subsequent extrasystole. In heterogeneous tissue, however, a premature extrasystole can either reduce or enhance the dispersion of refractoriness depending on its propagation direction with respect to the previous beat. With multiple extrasystoles at random coupling intervals, vulnerability to conduction block is proportional to their number. In general, steep action potential duration restitution and broad conduction velocity restitution promote dispersion of refractoriness in response to multiple extrasystoles, and thus enhance vulnerability to conduction block. These restitution properties also promote spatially discordant alternans, a setting which is particularly prone to conduction block. The equivalent dispersion of refractoriness created dynamically in homogeneous tissue by spatially discordant alternans is more likely to cause conduction block than a comparable degree of preexisting dispersion in heterogeneous tissue.

    Vulnerable window for conduction block in a one-dimensional cable of cardiac cells, 2: multiple extrasystoles. Publishing Authors By Initials

    z quZ Qu,a garfinkelA Garfinkel,jn weissJN Weiss,

    For similar abstracts research abstracts see: abstracts research

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    Vulnerable window for conduction block in a one-dimensional cable of cardiac cells, 2: multiple extrasystoles. Journal Published:

    PUBLICATION TYPE: Research Support, Non-U.S. Gov

    Journal: Biophysical journal

    VOLUME: 91

    Page Numbers: 805-15

    Journal Abbreviation:

    ISSN: 0006-3495

    DAY: 5

    MONTH: 05

    YEAR: 2006

    Vulnerable window for conduction block in a one-dimensional cable of cardiac cells, 2: multiple extrasystoles. Information

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    LANGUAGE: eng

    NlmUniqueID: 370626

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    Grant and Affiliation Information for Vulnerable window for conduction block in a one-dimensional cable of cardiac cells, 2: multiple extrasystoles.

    AFFILIATION: Department of Medicine Cardiology, David Geffen School of Medicine, University of California, Los Angeles, 90095, USA. zqu@mednet.ucla.edu

    Country: United States

    United States Research PublicationUnited States Research Publication

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    MEDLINETA: Biophys J

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