Special Feature

User Panel

My Panel

My Panel

Bookmark Science Articles

Recent News
Bookmark / Share This Science Site

Vulnerable window for conduction block in a one-dimensional cable of cardiac cells, 1: single extrasystoles.

Vulnerable window for conduction block in a one-dimensional cable of cardiac cells, 1: single extrasystoles. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

  • Abstract Text of This Paper
  • Journal Published
  • MeSH Keywords of This Abstract
  • Chemicals and Substances Used in this Paper
  • Grants and Granting Agency of this Research
  • Database Accession Numbers Used in this Paper
  • Related Papers
  • Related Research Tags
  • Rate this Research Paper
  • Vulnerable window for conduction block in a one-dimensional cable of cardiac cells, 1: single extrasystoles. Abstract Text:

    zhilin quZhilin Qu,alan garfinkelAlan Garfinkel,james n weissJames N Weiss,

    Spatial dispersion of refractoriness, which is amplified by genetic diseases, drugs, and electrical and structural remodeling during heart disease, is recognized as a major factor increasing the risk of lethal arrhythmias and sudden cardiac death. Dispersion forms the substrate for unidirectional conduction block, which is required for the initiation of reentry by extrasystoles or rapid pacing. In this study, we examine theoretically and numerically how preexisting gradients in refractoriness control the vulnerable window for unidirectional conduction block by a single premature extrasystole. Using a kinematic model to represent wavefront-waveback interactions, we first analytically derived the relationship (under simplified conditions) between the vulnerable window and various electrophysiological parameters such as action potential duration gradients, refractoriness barriers, conduction velocity restitution, etc. We then compared these findings to numerical simulations using the kinematic model or the Luo-Rudy action potential model in a one-dimensional cable of cardiac cells. The results from all three methods agreed well. We show that a critical gradient in action potential duration for conduction block can be analytically derived, and once this critical gradient is exceeded, the vulnerable window increases proportionately with the refractory barrier and is modulated by conduction velocity restitution and gap junctional conductance. Moreover, the critical gradient for conduction block is higher for an extrasystole traveling in the opposite direction from the sinus beat than for one traveling in the same direction (e.g., an epicardial extrasystole versus an endocardial extrasystole).

    Vulnerable window for conduction block in a one-dimensional cable of cardiac cells, 1: single extrasystoles. Publishing Authors By Initials

    z quZ Qu,a garfinkelA Garfinkel,jn weissJN Weiss,

    For similar abstracts research abstracts see: abstracts research

    PUBMED ID PMID:

    MEDLINE DATE:

    Vulnerable window for conduction block in a one-dimensional cable of cardiac cells, 1: single extrasystoles. Journal Published:

    PUBLICATION TYPE: Research Support, Non-U.S. Gov

    Journal: Biophysical journal

    VOLUME: 91

    Page Numbers: 793-804

    Journal Abbreviation:

    ISSN: 0006-3495

    DAY: 5

    MONTH: 05

    YEAR: 2006

    Vulnerable window for conduction block in a one-dimensional cable of cardiac cells, 1: single extrasystoles. Information

    Number of References:

    LANGUAGE: eng

    NlmUniqueID: 370626

    Vulnerable window for conduction block in a one-dimensional cable of cardiac cells, 1: single extrasystoles. Keywords Mesh Terms:

    KEYWORDS:

    MESH TERMS:

    Chemical & Substance for Abstract: Vulnerable window for conduction block in a one-dimensional cable of cardiac cells, 1: single extrasystoles. Information

    Substance Name:

    Registry Number:

    Grant and Affiliation Information for Vulnerable window for conduction block in a one-dimensional cable of cardiac cells, 1: single extrasystoles.

    AFFILIATION: Department of Medicine Cardiology, David Geffen School of Medicine, University of California, Los Angeles, 90095, USA. zqu@mednet.ucla.edu

    Country: United States

    United States Research PublicationUnited States Research Publication

    AGENCY:

    GRANT:

    ACRONYM:

    MEDLINETA: Biophys J

    REFSOURCE:

    DATABASENAME:

    ACCESSION NUMBER:

    Number Hits: 0

    Vulnerable window for conduction block in a one-dimensional cable of cardiac cells, 1: single extrasystoles Related Publications

     

    Molecular Station USER Menu

    Welcome to Molecular Station!

    You have to register before you can post on our forums or use our advanced features. Register Now! Its Free and Fast!

    Already registered? Login now below.

    User Name:

    Password:

    Already registered and Forgot your password? Click below to recover it.

    Recover Lost Password

    Join now - it's fast and free!

    Molecular Station is THE largest network of researchers, scientists and science lovers anywhere!

    Research Terms of Usage and Disclaimer
    Home
    Features

    Protocols

    DNA Forum

    Science Forum

    DNA Forum
    Biology Forum

    Science News


    [CaRP] XML error: Invalid document end at line 2

    For more click here:Science News