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Tripartite motif-containing 29 (TRIM29) is a novel marker for lymph node metastasis in gastric cancer.

Tripartite motif-containing 29 (TRIM29) is a novel marker for lymph node metastasis in gastric cancer. Research Abstract Details 

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  • Tripartite motif-containing 29 (TRIM29) is a novel marker for lymph node metastasis in gastric cancer. Abstract Text:

    yoshimasa kosakaYoshimasa Kosaka,hiroshi inoueHiroshi Inoue,takahiro ohmachiTakahiro Ohmachi,takeshi yokoeTakeshi Yokoe,toshifumi matsumotoToshifumi Matsumoto,koshi mimoriKoshi Mimori,fumiaki tanakaFumiaki Tanaka,masahiko watanabeMasahiko Watanabe,masaki moriMasaki Mori,yoshimasa kosakaYoshimasa Kosaka,hiroshi inoueHiroshi Inoue,takahiro ohmachiTakahiro Ohmachi,takeshi yokoeTakeshi Yokoe,toshifumi matsumotoToshifumi Matsumoto,koshi mimoriKoshi Mimori,fumiaki tanakaFumiaki Tanaka,masahiko watanabeMasahiko Watanabe,masaki moriMasaki Mori,

    BACKGROUND: Tripartite motif-containing 29 (TRIM29) belongs to the TRIM protein family, which has unique structural characteristics, including multiple zinc finger motifs and a leucine zipper motif. TRIM29, also known as ataxia telangiectasia group D complementing gene, possesses radiosensitivity suppressor functions. Although TRIM29 has been reported to be underexpressed in prostate and breast cancer, its expression in gastrointestinal cancer has not been studied. METHODS: By use of real-time reverse transcriptase-polymerase chain reaction, we analyzed TRIM29 mRNA expression status with respect to various clinicopathological parameters in 124 patients with gastric cancer. An immunohistochemical study was also conducted. RESULTS: The expression of TRIM29 was far higher in gastric cancer tumor tissue. Increased TRIM29 mRNA expression was markedly associated with such parameters as histological grade, large tumor size, extent of tumor invasion, and lymph node metastasis. In the TRIM29 high-expression group, it was an independent predictor for lymph node metastasis. Furthermore, patients with high TRIM29 mRNA expression showed a far poorer survival rate than those with low TRIM29 mRNA expression. CONCLUSIONS: TRIM29 expression may serve as a good marker of lymph node metastasis in gastric cancer.

    Tripartite motif-containing 29 (TRIM29) is a novel marker for lymph node metastasis in gastric cancer. Publishing Authors By Initials

    y kosakaY Kosaka,h inoueH Inoue,t ohmachiT Ohmachi,t yokoeT Yokoe,t matsumotoT Matsumoto,k mimoriK Mimori,f tanakaF Tanaka,m watanabeM Watanabe,m moriM Mori,y kosakaY Kosaka,h inoueH Inoue,t ohmachiT Ohmachi,t yokoeT Yokoe,t matsumotoT Matsumoto,k mimoriK Mimori,f tanakaF Tanaka,m watanabeM Watanabe,m moriM Mori,

    For similar abstracts research abstracts see: abstracts research

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    Tripartite motif-containing 29 (TRIM29) is a novel marker for lymph node metastasis in gastric cancer. Journal Published:

    PUBLICATION TYPE: Research Support, Non-U.S. Gov

    Journal: Annals of surgical oncology

    VOLUME: 14

    Page Numbers: 2543-9

    Journal Abbreviation: Ann. Surg. Oncol.

    ISSN: 1068-9265

    DAY: 28

    MONTH: 06

    YEAR: 2007

    Tripartite motif-containing 29 (TRIM29) is a novel marker for lymph node metastasis in gastric cancer. Information

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    LANGUAGE: eng

    NlmUniqueID: 9420840

    Tripartite motif-containing 29 (TRIM29) is a novel marker for lymph node metastasis in gastric cancer. Keywords Mesh Terms:

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    Grant and Affiliation Information for Tripartite motif-containing 29 (TRIM29) is a novel marker for lymph node metastasis in gastric cancer.

    AFFILIATION: Department of Surgical Oncology, Medical Institute of Bioregulation, Kyushu University, 4546, Tsurumihara, Beppu, 874-0838, Japan.

    Country: United States

    United States Research PublicationUnited States Research Publication

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    MEDLINETA: Ann Surg Oncol

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