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Transplantation of multipotent astrocytic stem cells into a rat model of neonatal hypoxic-ischemic encephalopathy.

Transplantation of multipotent astrocytic stem cells into a rat model of neonatal hypoxic-ischemic encephalopathy. Research Abstract Details 

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  • Transplantation of multipotent astrocytic stem cells into a rat model of neonatal hypoxic-ischemic encephalopathy. Abstract Text:

    tong zhengTong Zheng,candace rossignolCandace Rossignol,avital leiboviciAvital Leibovici,kevin j andersonKevin J Anderson,dennis a steindlerDennis A Steindler,michael d weissMichael D Weiss,

    Hypoxic-ischemic encephalopathy (HIE) in neonates results in long-term disabilities. Stem cell therapy may offer an attractive treatment for HIE. Multipotent astrocytic stem cells (MASCs) from mice transplanted into a rat model of hypoxia-ischemia (HI) survived the transplantation and showed signs of migration towards the injured cortex. Some MASCs around the injured cortex differentiated into neuronal and astrocytic phenotypes. MASCs transplanted into non-ischemic pups survived but retained their astrocytic phenotype. These data suggest that transplanted MASCs can survive and differentiate into neurons and astrocytes in the post-injury milieu of the neonatal brain injured by HI.

    Transplantation of multipotent astrocytic stem cells into a rat model of neonatal hypoxic-ischemic encephalopathy. Publishing Authors By Initials

    t zhengT Zheng,c rossignolC Rossignol,a leiboviciA Leibovici,kj andersonKJ Anderson,da steindlerDA Steindler,md weissMD Weiss,

    For similar abstracts research abstracts see: abstracts research

    PUBMED ID PMID:

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    Transplantation of multipotent astrocytic stem cells into a rat model of neonatal hypoxic-ischemic encephalopathy. Journal Published:

    PUBLICATION TYPE: Research Support, Non-U.S. Gov

    Journal: Brain research

    VOLUME: 1112

    Page Numbers: 99-105

    Journal Abbreviation:

    ISSN: 0006-8993

    DAY: 21

    MONTH: 08

    YEAR: 2006

    Transplantation of multipotent astrocytic stem cells into a rat model of neonatal hypoxic-ischemic encephalopathy. Information

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    LANGUAGE: eng

    NlmUniqueID: 45503

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    Grant and Affiliation Information for Transplantation of multipotent astrocytic stem cells into a rat model of neonatal hypoxic-ischemic encephalopathy.

    AFFILIATION: McKnight Brain Institute, University of Florida, Gainesville, FL, USA.

    Country: Netherlands

    Netherlands Research PublicationNetherlands Research Publication

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    MEDLINETA: Brain Res

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