Transplantation of multipotent astrocytic stem cells into a rat model of neonatal hypoxic-ischemic encephalopathy.

Transplantation of multipotent astrocytic stem cells into a rat model of neonatal hypoxic-ischemic encephalopathy. Research Abstract Details 

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Transplantation of multipotent astrocytic stem cells into a rat model of neonatal hypoxic-ischemic encephalopathy. Abstract Text:

Tong Zheng,Candace Rossignol,Avital Leibovici,Kevin J Anderson,Dennis A Steindler,Michael D Weiss,

Hypoxic-ischemic encephalopathy (HIE) in neonates results in long-term disabilities. Stem cell therapy may offer an attractive treatment for HIE. Multipotent astrocytic stem cells (MASCs) from mice transplanted into a rat model of hypoxia-ischemia (HI) survived the transplantation and showed signs of migration towards the injured cortex. Some MASCs around the injured cortex differentiated into neuronal and astrocytic phenotypes. MASCs transplanted into non-ischemic pups survived but retained their astrocytic phenotype. These data suggest that transplanted MASCs can survive and differentiate into neurons and astrocytes in the post-injury milieu of the neonatal brain injured by HI.

Transplantation of multipotent astrocytic stem cells into a rat model of neonatal hypoxic-ischemic encephalopathy. Publishing Authors By Initials

T Zheng,C Rossignol,A Leibovici,KJ Anderson,DA Steindler,MD Weiss,

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Transplantation of multipotent astrocytic stem cells into a rat model of neonatal hypoxic-ischemic encephalopathy. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Brain research

VOLUME: 1112

Page Numbers: 99-105

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ISSN: 0006-8993

DAY: 21

MONTH: 08

YEAR: 2006

Transplantation of multipotent astrocytic stem cells into a rat model of neonatal hypoxic-ischemic encephalopathy. Information

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LANGUAGE: eng

NlmUniqueID: 45503

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Grant and Affiliation Information for Transplantation of multipotent astrocytic stem cells into a rat model of neonatal hypoxic-ischemic encephalopathy.

AFFILIATION: McKnight Brain Institute, University of Florida, Gainesville, FL, USA.

Country: Netherlands

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MEDLINETA: Brain Res

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