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The glycosylphosphatidylinositol anchor: a complex membrane-anchoring structure for proteins.

The glycosylphosphatidylinositol anchor: a complex membrane-anchoring structure for proteins. Research Abstract Details 

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  • The glycosylphosphatidylinositol anchor: a complex membrane-anchoring structure for proteins. Abstract Text:

    Positioned at the C-terminus of many eukaryotic proteins, the glycosylphosphatidylinositol (GPI) anchor is a posttranslational modification that anchors the modified protein in the outer leaflet of the cell membrane. The GPI anchor is a complex structure comprising a phosphoethanolamine linker, glycan core, and phospholipid tail. GPI-anchored proteins are structurally and functionally diverse and play vital roles in numerous biological processes. While several GPI-anchored proteins have been characterized, the biological functions of the GPI anchor have yet to be elucidated at a molecular level. This review discusses the structural diversity of the GPI anchor and its putative cellular functions, including involvement in lipid raft partitioning, signal transduction, targeting to the apical membrane, and prion disease pathogenesis. We specifically highlight studies in which chemically synthesized GPI anchors and analogues have been employed to study the roles of this unique posttranslational modification.

    The glycosylphosphatidylinositol anchor: a complex membrane-anchoring structure for proteins. Publishing Authors By Initials

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    The glycosylphosphatidylinositol anchor: a complex membrane-anchoring structure for proteins. Journal Published:

    PUBLICATION TYPE: Research Support, Non-U.S. Gov

    Journal: Biochemistry

    VOLUME: 47

    Page Numbers: 6991-7000

    Journal Abbreviation: Biochemistry

    ISSN: 1520-4995

    DAY: 17

    MONTH: 06

    YEAR: 2008

    The glycosylphosphatidylinositol anchor: a complex membrane-anchoring structure for proteins. Information

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    LANGUAGE: eng

    NlmUniqueID: 370623

    The glycosylphosphatidylinositol anchor: a complex membrane-anchoring structure for proteins. Keywords Mesh Terms:

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    Grant and Affiliation Information for The glycosylphosphatidylinositol anchor: a complex membrane-anchoring structure for proteins.

    AFFILIATION: Department of Chemistry, University of California, Berkeley, California 94720, USA.

    Country: United States

    United States Research PublicationUnited States Research Publication

    AGENCY: United States Howard Hugh

    GRANT: GM59907

    ACRONYM: GM

    MEDLINETA: Biochemistry

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