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Snake venom components affecting blood coagulation and the vascular system: structural similarities and marked diversity.

Snake venom components affecting blood coagulation and the vascular system: structural similarities and marked diversity. Research Abstract Details 

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  • Snake venom components affecting blood coagulation and the vascular system: structural similarities and marked diversity. Abstract Text:

    yasuo yamazakiYasuo Yamazaki,takashi moritaTakashi Morita,yasuo yamazakiYasuo Yamazaki,takashi moritaTakashi Morita,

    In studies of blood coagulation and the vascular system, snake venom toxins have been indispensable in elucidating the complex physiological mechanisms that govern coagulation and the vascular system in mammals, given their potency and highly specific biological effects. The various components of snake venom toxins can be classified according to their mechanism of action, for example, serine proteases, metalloproteinases, Kunitz-type protease inhibitors, phospholipases A(2), (L)-amino acid oxidases, C-type lectin(-like) proteins, disintegrins, vascular endothelial growth factors, three-finger toxins, and cysteine-rich secretory proteins. Although the molecular structures of most toxins are not unique to snake venom toxins, venom proteins often exhibit marked diversity in their biological effects, despite their structural similarities. In this review, we identify several snake venom toxins capable of affecting blood coagulation and the vascular system, as well as various toxins from other organisms, including leeches and ticks.

    Snake venom components affecting blood coagulation and the vascular system: structural similarities and marked diversity. Publishing Authors By Initials

    y yamazakiY Yamazaki,t moritaT Morita,y yamazakiY Yamazaki,t moritaT Morita,

    For similar abstracts research abstracts see: abstracts research

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    Snake venom components affecting blood coagulation and the vascular system: structural similarities and marked diversity. Journal Published:

    PUBLICATION TYPE: Review

    Journal: Current pharmaceutical design

    VOLUME: 13

    Page Numbers: 2872-86

    Journal Abbreviation: Curr. Pharm. Des.

    ISSN: 1873-4286

    DAY: 5

    MONTH: 11

    YEAR: 2007

    Snake venom components affecting blood coagulation and the vascular system: structural similarities and marked diversity. Information

    Number of References: 176

    LANGUAGE: eng

    NlmUniqueID: 9602487

    Snake venom components affecting blood coagulation and the vascular system: structural similarities and marked diversity. Keywords Mesh Terms:

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    Grant and Affiliation Information for Snake venom components affecting blood coagulation and the vascular system: structural similarities and marked diversity.

    AFFILIATION: Department of Biochemistry, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.

    Country: Netherlands

    Netherlands Research PublicationNetherlands Research Publication

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    MEDLINETA: Curr Pharm Des

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