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Serum vitronectin receptor in alcoholic liver disease: correlation with fibronectin receptor and morphological features.

Serum vitronectin receptor in alcoholic liver disease: correlation with fibronectin receptor and morphological features. Research Abstract Details 

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  • Serum vitronectin receptor in alcoholic liver disease: correlation with fibronectin receptor and morphological features. Abstract Text:

    In order to clarify the significance of serum level of vitronectin receptor (VNR) in alcoholic liver disease (ALD), we have investigated the relationship with fibronectin receptor (FNR) and histological liver features in 21 ALD patients. Serum level of VNR and FNR was measured by enzyme immunoassay. Liver disease activity was scored based on levels of fibrosis and focal intralobular necrosis and degeneration. The serum level of VNR (micrograms/ml) was significantly higher in the patients with hepatic fibrosis (9.87 +/- 2.51) and liver cirrhosis (10.80 +/- 1.52) than in normal subjects (5.51 +/- 0.52, P < 0.01) and fatty liver subjects (6.58 +/- 0.58, P < 0.05). A positive correlation was found between serum levels of VNR and fibronectin receptor (FNR) (P < 0.05). A positive correlation was observed between the serum level of FNR and the degree of hepatic fibrosis or focal intralobular necrosis and degeneration, while no correlation was found between the serum level of VNR and the degree of histological features. A positive correlation was also noted between the serum level of FNR and N-terminal type III procollagen aminopeptide (PIIIP) (P < 0.001), while no correlation was observed between the serum level of VNR and PIIIP. We conclude that the serum level of VNR is increased in patients with advanced alcoholic liver disease. However, the mechanism by which serum levels of beta subunit of VNR and FNR are increased may be different.

    Serum vitronectin receptor in alcoholic liver disease: correlation with fibronectin receptor and morphological features. Publishing Authors By Initials

    For similar proteins: membrane proteins: receptors, cell surface: receptors, immunologic: integrins: receptors, cytoadhesin: receptors, vitronectin research abstracts see: proteins: membrane proteins: receptors, cell surface: receptors, immunologic: integrins: receptors, cytoadhesin: receptors, vitronectin research

    PUBMED ID PMID:

    MEDLINE DATE:

    Serum vitronectin receptor in alcoholic liver disease: correlation with fibronectin receptor and morphological features. Journal Published:

    PUBLICATION TYPE: Research Support, Non-U.S. Gov

    Journal: Alcohol and alcoholism (Oxford, Oxfordshire). Supp

    VOLUME: 1A

    Page Numbers: 37-43

    Journal Abbreviation:

    ISSN: 1358-6173

    DAY: 26

    MONTH: 02

    YEAR: 1993

    Serum vitronectin receptor in alcoholic liver disease: correlation with fibronectin receptor and morphological features. Information

    Number of References:

    LANGUAGE: eng

    NlmUniqueID: 8804836

    Serum vitronectin receptor in alcoholic liver disease: correlation with fibronectin receptor and morphological features. Keywords Mesh Terms:

    KEYWORDS: Receptors, Vitronectin

    MESH TERMS: analysis

    Chemical & Substance for Abstract: Serum vitronectin receptor in alcoholic liver disease: correlation with fibronectin receptor and morphological features. Information

    Substance Name: Receptors, Vitronectin

    Registry Number: 0

    Grant and Affiliation Information for Serum vitronectin receptor in alcoholic liver disease: correlation with fibronectin receptor and morphological features.

    AFFILIATION: First Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.

    Country: ENGLAND

    ENGLAND Research Publication

    AGENCY:

    GRANT:

    ACRONYM:

    MEDLINETA: Alcohol Alcohol Suppl

    REFSOURCE:

    DATABASENAME:

    ACCESSION NUMBER:

    Number Hits: 0

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