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Serum level of carbohydrate-deficient transferrin as a marker of alcoholic liver disease.

Serum level of carbohydrate-deficient transferrin as a marker of alcoholic liver disease. Research Abstract Details 

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  • Serum level of carbohydrate-deficient transferrin as a marker of alcoholic liver disease. Abstract Text:

    Serum levels of carbohydrate-deficient transferrin (CDT) were assayed in 87 patients with alcoholic liver disease, 25 alcoholics without liver disease, 25 cases with viral liver disease and 37 healthy subjects, by two different methods (Pharmacia CDT RIA kit and Axis % CDT kit). The serum level of Pharmacia-CDT was significantly higher in the patients with alcoholic liver disease (38.9 +/- 2.8 U/l) compared to the normal subjects (18.9 +/- 0.2 U/l), alcoholics without liver disease (21.7 +/- 1.5 U/l) and non-alcoholic liver disease (viral liver disease) (23.4 +/- 1.6 U/l) (P < 0.001). The serum level of Axis-CDT was also significantly higher in the patients with alcoholic liver disease (4.22 +/- 0.48%) compared to the normal subjects (0.84 +/- 0.14%), alcoholics without liver disease (1.14 +/- 0.23%) and non-alcoholic liver disease (1.84 +/- 0.29%) (P < 0.001). A significant correlation was found between serum levels of CDT determined by the two kits (r = 0.718, P < 0.001). The serum level of Axis-CDT was significantly higher in patients with alcoholic hepatitis compared to the normal subjects (P < 0.005), while the serum level of Pharmacia-CDT was not increased in the patients with alcoholic hepatitis. These results indicate that determination of serum CDT levels is a useful marker of alcoholic liver disease, not a marker for alcohol consumption. Axis-CDT is more useful than Pharmacia-CDT for assaying the serum level of CDT in patients with alcoholic liver disease.

    Serum level of carbohydrate-deficient transferrin as a marker of alcoholic liver disease. Publishing Authors By Initials

    For similar proteins: blood proteins: acute-phase proteins: transferrin research abstracts see: proteins: blood proteins: acute-phase proteins: transferrin research

    PUBMED ID PMID:

    MEDLINE DATE:

    Serum level of carbohydrate-deficient transferrin as a marker of alcoholic liver disease. Journal Published:

    PUBLICATION TYPE: Research Support, Non-U.S. Gov

    Journal: Alcohol and alcoholism (Oxford, Oxfordshire). Supp

    VOLUME: 1B

    Page Numbers: 3-8

    Journal Abbreviation:

    ISSN: 1358-6173

    DAY: 26

    MONTH: 02

    YEAR: 1993

    Serum level of carbohydrate-deficient transferrin as a marker of alcoholic liver disease. Information

    Number of References:

    LANGUAGE: eng

    NlmUniqueID: 8804836

    Serum level of carbohydrate-deficient transferrin as a marker of alcoholic liver disease. Keywords Mesh Terms:

    KEYWORDS: Transferrin

    MESH TERMS: analysis

    Chemical & Substance for Abstract: Serum level of carbohydrate-deficient transferrin as a marker of alcoholic liver disease. Information

    Substance Name: Transferrin

    Registry Number: 11096-37-0

    Grant and Affiliation Information for Serum level of carbohydrate-deficient transferrin as a marker of alcoholic liver disease.

    AFFILIATION: First Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.

    Country: ENGLAND

    ENGLAND Research Publication

    AGENCY:

    GRANT:

    ACRONYM:

    MEDLINETA: Alcohol Alcohol Suppl

    REFSOURCE:

    DATABASENAME:

    ACCESSION NUMBER:

    Number Hits: 0

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