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Quantitative characterization of the corticospinal tract at 3T.

Quantitative characterization of the corticospinal tract at 3T. Research Abstract Details 

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  • Quantitative characterization of the corticospinal tract at 3T. Abstract Text:

    d s reichD S Reich,s a smithS A Smith,c k jonesC K Jones,k m zackowskiK M Zackowski,p c van zijlP C van Zijl,p a calabresiP A Calabresi,s moriS Mori,d s reichD S Reich,s a smithS A Smith,c k jonesC K Jones,k m zackowskiK M Zackowski,p c van zijlP C van Zijl,p a calabresiP A Calabresi,s moriS Mori,

    BACKGROUND AND PURPOSE: White matter tract-specific imaging will probably become a major component of clinical neuroradiology. Fiber tracking with diffusion tensor imaging (DTI) is widely used, but variability is substantial. This article reports the ranges of MR imaging appearance and right-left asymmetry of healthy corticospinal tracts (CST) reconstructed with DTI. METHODS: For 20 healthy volunteers, whole-brain DTI data were coregistered with maps of absolute T1 and T2 relaxation times and magnetization transfer ratio (MTR), all acquired at 3T. For each individual, the 2 reconstructed CSTs and their asymmetry were analyzed with respect to the number of fibers reconstructed; tract volume; and individual MR imaging parameters restricted to the tracts. Interscan variability was estimated by repeat imaging of 8 individuals. RESULTS: Reconstructed fiber number and tract volume are highly variable, rendering them insensitive to abnormalities in disease. Individual tract-restricted MR imaging parameters are more constrained, and their population averages and normal ranges are reported. The average population asymmetry is generally zero; therefore, normal ranges for an index of asymmetry are reported. By way of example, CST-restricted MR imaging parameters and their asymmetries are shown to be abnormal in an individual with multiple sclerosis who had a lesion affecting the CST. CONCLUSIONS: The results constitute a normative dataset for the following imaging parameters of the CST: T1, T2, MTR, fractional anisotropy, mean diffusivity, transverse diffusivity, and the 3 diffusion tensor eigenvalues. These data can be used to identify, characterize, and establish the significance of changes in diseases that affect the CST.

    Quantitative characterization of the corticospinal tract at 3T. Publishing Authors By Initials

    ds reichDS Reich,sa smithSA Smith,ck jonesCK Jones,km zackowskiKM Zackowski,pc van zijlPC van Zijl,pa calabresiPA Calabresi,s moriS Mori,ds reichDS Reich,sa smithSA Smith,ck jonesCK Jones,km zackowskiKM Zackowski,pc van zijlPC van Zijl,pa calabresiPA Calabresi,s moriS Mori,

    For similar nervous system: central nervous system: spinal cord: pyramidal tracts research abstracts see: nervous system: central nervous system: spinal cord: pyramidal tracts research

    PUBMED ID PMID:

    MEDLINE DATE:

    Quantitative characterization of the corticospinal tract at 3T. Journal Published:

    PUBLICATION TYPE: Research Support, Non-U.S. Gov

    Journal: AJNR. American journal of neuroradiology

    VOLUME: 27

    Page Numbers: 2168-78

    Journal Abbreviation:

    ISSN: 0195-6108

    DAY: 3

    MONTH: 12

    YEAR: 2007

    Quantitative characterization of the corticospinal tract at 3T. Information

    Number of References:

    LANGUAGE: eng

    NlmUniqueID: 8003708

    Quantitative characterization of the corticospinal tract at 3T. Keywords Mesh Terms:

    KEYWORDS: Pyramidal Tracts

    MESH TERMS: anatomy & histology

    Chemical & Substance for Abstract: Quantitative characterization of the corticospinal tract at 3T. Information

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    Grant and Affiliation Information for Quantitative characterization of the corticospinal tract at 3T.

    AFFILIATION: Department of Neurology, Johns Hopkins University, Baltimore, MD, USA. dreich2@jhmi.edu

    Country: United States

    United States Research PublicationUnited States Research Publication

    AGENCY: United States NCRR

    GRANT: RR15241

    ACRONYM: RR

    MEDLINETA: AJNR Am J Neuroradiol

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