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Proteomic study on X-irradiation-responsive proteins and ageing: search for responsible proteins for radiation adaptive response.

Proteomic study on X-irradiation-responsive proteins and ageing: search for responsible proteins for radiation adaptive response. Research Abstract Details 

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  • Proteomic study on X-irradiation-responsive proteins and ageing: search for responsible proteins for radiation adaptive response. Abstract Text:

    yuri miuraYuri Miura,mayumi kanoMayumi Kano,masaki yamadaMasaki Yamada,tsutomu nishineTsutomu Nishine,shiro uranoShiro Urano,shozo suzukiShozo Suzuki,tamao endoTamao Endo,tosifusa todaTosifusa Toda,yuri miuraYuri Miura,mayumi kanoMayumi Kano,masaki yamadaMasaki Yamada,tsutomu nishineTsutomu Nishine,shiro uranoShiro Urano,shozo suzukiShozo Suzuki,tamao endoTamao Endo,tosifusa todaTosifusa Toda,

    We investigated high- or low-dose irradiation-responsive proteins using proteomics on two-dimensional (2D) PAGE, and the effects of ageing on cell responses to radiation in variously aged rat astrocytes. After 5 Gy irradiation, the relative abundance of peroxiredoxin 2, an antioxidant enzyme, and latexin, an inhibitor of carboxypeptidase, increased. The induction of these proteins was suppressed by ageing, suggesting that the response to high-dose radiation decreased with ageing. The relative abundance of elongation factor 2 (EF-2) fragment increased 3 h and reduced 24 h after 0.1 Gy irradiation. Temporal enhancement of the EF-2 fragment due to low-dose irradiation was suppressed by ageing. Since radiation adaptive response in cultured astrocytes was observed 3 h but not 24 h after 0.1 Gy irradiation and suppressed by ageing as previously reported, alteration of the EF-2 fragment corresponded to the radiation adaptive response. We also examined phospho-protein profiles, resulting in the relative abundance of phospho-EF-1beta and phospho-beta-actin being altered by 0.1 Gy irradiation; however, ageing did not affect the alteration of phospho-EF-1beta and phospho-beta-actin, unlike the EF-2 fragment. The results suggested that the EF-2 fragment was a possible candidate for the protein responsible for the radiation adaptive response in cultured astrocytes.

    Proteomic study on X-irradiation-responsive proteins and ageing: search for responsible proteins for radiation adaptive response. Publishing Authors By Initials

    y miuraY Miura,m kanoM Kano,m yamadaM Yamada,t nishineT Nishine,s uranoS Urano,s suzukiS Suzuki,t endoT Endo,t todaT Toda,y miuraY Miura,m kanoM Kano,m yamadaM Yamada,t nishineT Nishine,s uranoS Urano,s suzukiS Suzuki,t endoT Endo,t todaT Toda,

    For similar abstracts research abstracts see: abstracts research

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    Proteomic study on X-irradiation-responsive proteins and ageing: search for responsible proteins for radiation adaptive response. Journal Published:

    PUBLICATION TYPE: Research Support, Non-U.S. Gov

    Journal: Journal of biochemistry

    VOLUME: 142

    Page Numbers: 145-55

    Journal Abbreviation: J. Biochem.

    ISSN: 0021-924X

    DAY: 23

    MONTH: 05

    YEAR: 2007

    Proteomic study on X-irradiation-responsive proteins and ageing: search for responsible proteins for radiation adaptive response. Information

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    LANGUAGE: eng

    NlmUniqueID: 376600

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    Grant and Affiliation Information for Proteomic study on X-irradiation-responsive proteins and ageing: search for responsible proteins for radiation adaptive response.

    AFFILIATION: Research Team for Functional Genomics, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakaecho, Itabashi-ku, Tokyo 173-0015, Japan. miura@center.tmig.or.jp

    Country: Japan

    Japan Research PublicationJapan Research Publication

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    MEDLINETA: J Biochem (Tokyo)

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