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- Disulfide bridge based PEGylation of proteins. PEGylation is a clinically proven strategy for increasing the therapeutic efficacy of protein-based medicines. Our approach to site-specific PEGylation...

- Drosophila PIWI associates with chromatin and interacts directly with HP1a. The interface between cellular systems involving small noncoding RNAs and epigenetic change remains largely unexplored in metazoans. RNA-induced silencing...

- DTPA-coupled proteins--procedures and precautions. While demonstrating that the cyclic anhydride of diethylenetriaminepentaacetic acid (DTPA) may be used to covalently attach this chelator to proteins, it was...

- Dual localization: proteins in extracellular and intracellular compartments. The goal of this article is to provide a comprehensive catalog of those proteins documented to exhibit dual localization, being found in both the...

- Effect of catenation on protein folding stability. Building on previous studies of the effects of covalent linking and backbone cyclization on protein folding stability, a theory is developed for the...

- Effect of forskolin on collagen production in clonal osteoblastic MC3T3-E1 cells. The effect of forskolin on collagen production in osteoblasts was investigated by using clonal osteoblastic MC3T3-E1 cells cultured in a-minimum essential...

- Effect of intermittent feeding with high-fat diet on changes of glycogen, protein and fat content in liver and skeletal muscle in the laboratory mouse. After 8 weeks of intermittent fasting, mice fed both a standard laboratory diet and a high-fat diet became hyperphagic and showed an increased amount of...

- Effect of intravenous amino acids on protein kinetics in preterm infants. PURPOSE OF REVIEW: To summarize recent findings of the effects of intravenous amino acids on protein kinetics in low-birth-weight infants and to describe the...

- Effects of amino acid composition, finite size of proteins, and sparse statistics on distance-dependent statistical pair potentials. Statistical distance dependent pair potentials are frequently used in a variety of folding, threading, and modeling studies of proteins. The applicability of...

- Effects of side-chain orientation on the 13C chemical shifts of antiparallel beta-sheet model peptides. The dependence of the (13)C chemical shift on side-chain orientation was investigated at the density functional level for a two-strand antiparallel...

- Efficient polymer monolith for strong cation-exchange capillary liquid chromatography of peptides. A stable poly[2-acrylamido-2-methyl-1-propanesulfonic acid-co-poly(ethylene glycol) diacrylate] monolith was synthesized inside a 75-microm-i.d. capillary by...

- Electron transporting components participating in nitrate and oxygen respirations from a halotolerant Micrococcus. II. Properties of cytochrome c551 and brown protein.

- Ensemble refinement of protein crystal structures: validation and application. X-ray crystallography typically uses a single set of coordinates and B factors to describe macromolecular conformations. Refinement of multiple copies of the...

- Enzyme activity and protein patterns as premalignant markers in mucosal biopsy specimens from the large intestine. Total enzyme activity of glucose-6-phosphate dehydrogenase (G6PD) and lactate dehydrogenase (LD) was measured in homogenates of resected biopsy specimens and...

- Enzyme complex nature of the reversible glycine cleavage system of cock liver mitochondria.

- Evaluation of biologically relevant short alpha-helices stabilized by a main-chain hydrogen-bond surrogate. We previously reported the design and synthesis of a new class of artificial alpha-helices in which an N-terminal main-chain hydrogen bond is replaced by a...

- Evaluation of etiological hypotheses and a study of early lesions in alcoholic pancreatitis. Current understanding of the pathology of chronic pancreatitis secondary to chronic alcoholism is exclusively based on surgical biopsies or autopsy studies...

- Evolving proteins in mammalian cells using somatic hypermutation. We describe a new method to mutate target genes through somatic hypermutation (SHM) and to evolve proteins directly in living mammalian cells. Target genes...

- Excimer-based peptide beacons: a convenient experimental approach for monitoring polypeptide-protein and polypeptide-oligonucleotide interactions.

- Exploitation of bile acid transport systems in prodrug design. The enterohepatic circulation of bile acids is one of the most efficient recycling routes in the human body. It is a complex process involving numerous...