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Preferential recognition of a microbial metabolite by human Vgamma2Vdelta2 T cells.

Preferential recognition of a microbial metabolite by human Vgamma2Vdelta2 T cells. Research Abstract Details 

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  • Preferential recognition of a microbial metabolite by human Vgamma2Vdelta2 T cells. Abstract Text:

    kia-joo puanKia-Joo Puan,chenggang jinChenggang Jin,hong wangHong Wang,ghanashyam sarikondaGhanashyam Sarikonda,amy m rakerAmy M Raker,hoi k leeHoi K Lee,megan i samuelsonMegan I Samuelson,elisabeth Elisabeth ,ljiljana pasa-tolicLjiljana Pasa-Tolic,edward nievesEdward Nieves, giner Giner,tomohisa kuzuyamaTomohisa Kuzuyama,craig t moritaCraig T Morita,

    Human Vgamma2Vdelta2 T cells are stimulated by prenyl pyrophosphates, such as isopentenyl pyrophosphate (IPP), and play important roles in mediating immunity against microbial pathogens and have potent anti-tumor activity. (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) has been identified as a metabolite in the 2-C-methyl-D-erythritol-4 phosphate (MEP) pathway for isoprenoid biosynthesis that is used by many bacteria and protozoan parasites. We find that HMBPP is the major Vgamma2Vdelta2 T-cell antigen for many bacteria, including Mycobacterium tuberculosis, Yersinia enterocolitica and Escherichia coli. HMBPP was a 30 000-fold more potent antigen than IPP. Using mutant bacteria, we show that bacterial antigen levels for Vgamma2Vdelta2 T cells are controlled by MEP pathway enzymes and find no evidence for the production of 3-formyl-1-butyl pyrophosphate. Moreover, HMBPP reactivity required only germ line-encoded Vgamma2Vdelta2 TCR elements and is present at birth. Importantly, we show that bacterial HMBPP levels correlated with their ability to expand Vgamma2Vdelta2 T cells in vivo upon engraftment into severe combined immunodeficiency-beige mice. Thus, the production of HMBPP by a microbial-specific isoprenoid pathway plays a major role in determining whether bacteria will stimulate Vgamma2Vdelta2 T cells in vivo. This preferential stimulation by a common microbial isoprenoid metabolite allows Vgamma2Vdelta2 T cells to respond to a broad array of pathogens using this pathway.

    Preferential recognition of a microbial metabolite by human Vgamma2Vdelta2 T cells. Publishing Authors By Initials

    kj puanKJ Puan,c jinC Jin,h wangH Wang,g sarikondaG Sarikonda,am rakerAM Raker,hk leeHK Lee,mi samuelsonMI Samuelson,e E ,l pasa-tolicL Pasa-Tolic,e nievesE Nieves,jl ginerJL Giner,t kuzuyamaT Kuzuyama,ct moritaCT Morita,

    For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: lymphocyte subsets: t-lymphocyte subsets research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: lymphocyte subsets: t-lymphocyte subsets research

    PUBMED ID PMID:

    MEDLINE DATE:

    Preferential recognition of a microbial metabolite by human Vgamma2Vdelta2 T cells. Journal Published:

    PUBLICATION TYPE: Research Support, U.S. Gov't,

    Journal: International immunology

    VOLUME: 19

    Page Numbers: 657-73

    Journal Abbreviation:

    ISSN: 0953-8178

    DAY: 19

    MONTH: 04

    YEAR: 2007

    Preferential recognition of a microbial metabolite by human Vgamma2Vdelta2 T cells. Information

    Number of References:

    LANGUAGE: eng

    NlmUniqueID: 8916182

    Preferential recognition of a microbial metabolite by human Vgamma2Vdelta2 T cells. Keywords Mesh Terms:

    KEYWORDS: T-Lymphocyte Subsets

    MESH TERMS: microbiology

    Chemical & Substance for Abstract: Preferential recognition of a microbial metabolite by human Vgamma2Vdelta2 T cells. Information

    Substance Name: isopentenyl pyrophosphate

    Registry Number: 358-71-4

    Grant and Affiliation Information for Preferential recognition of a microbial metabolite by human Vgamma2Vdelta2 T cells.

    AFFILIATION: Division of Rheumatology, Department of Internal Medicine and the Interdisciplinary Graduate Program in Immunology, University of Iowa College of Medicine, EMRB 400F, Iowa City, IA 52242, USA.

    Country: England

    England Research Publication

    AGENCY: United States NIAID

    GRANT: U54 AI057160

    ACRONYM: AI

    MEDLINETA: Int Immunol

    REFSOURCE:

    DATABASENAME:

    ACCESSION NUMBER:

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    Preferential recognition of a microbial metabolite by human Vgamma2Vdelta2 T cells Related Publications

     

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