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Possible role of vascular angiotensin converting enzyme in the genesis of hypertension.

Possible role of vascular angiotensin converting enzyme in the genesis of hypertension. Research Abstract Details 

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  • Possible role of vascular angiotensin converting enzyme in the genesis of hypertension. Abstract Text:

    m miyazakiM Miyazaki,t okamuraT Okamura,h okunishiH Okunishi,n todaN Toda,

    This study was designed to evaluate changes in angiotensin converting enzyme (ACE) activity in 2-kidney, 1-clip renal hypertensive dogs. Blood pressure increased and remained elevated for eight months after partial clamping of the left renal artery. Plasma renin activity was increased for one month after surgery, but then returned to the pre-clamping level. SA-446, a potent ACE inhibitor, reduced blood pressure in 8 M-hypertensive dogs. Plasma ACE activities was not altered during the course of hypertension, but vascular ACE activities in the pulmonary and mesenteric arteries and the aorta were significantly increased in 8 M-hypertensive dogs. These results may indicate that ACE plays an important role in the maintenance of chronic phase of 2-kidney, 1-clip renal hypertension and that suppression of vascular ACE activities might be a mechanism underlying the hypotensive effect of ACE inhibitors.

    Possible role of vascular angiotensin converting enzyme in the genesis of hypertension. Publishing Authors By Initials

    m miyazakiM Miyazaki,t okamuraT Okamura,h okunishiH Okunishi,n todaN Toda,

    For similar biochemical phenomena, metabolism, and nutrition: metabolism: renin-angiotensin system research abstracts see: biochemical phenomena, metabolism, and nutrition: metabolism: renin-angiotensin system research

    PUBMED ID PMID:

    MEDLINE DATE:

    Possible role of vascular angiotensin converting enzyme in the genesis of hypertension. Journal Published:

    PUBLICATION TYPE: Journal Article

    Journal: Clinical and experimental hypertension. Part A, Th

    VOLUME: 9

    Page Numbers: 435-40

    Journal Abbreviation:

    ISSN: 0730-0077

    DAY: 12

    MONTH: 02

    YEAR: 1987

    Possible role of vascular angiotensin converting enzyme in the genesis of hypertension. Information

    Number of References:

    LANGUAGE: eng

    NlmUniqueID: 8207790

    Possible role of vascular angiotensin converting enzyme in the genesis of hypertension. Keywords Mesh Terms:

    KEYWORDS: Renin-Angiotensin System

    MESH TERMS: drug effects

    Chemical & Substance for Abstract: Possible role of vascular angiotensin converting enzyme in the genesis of hypertension. Information

    Substance Name: Peptidyl-Dipeptidase A

    Registry Number: EC 3.4.15.1

    Grant and Affiliation Information for Possible role of vascular angiotensin converting enzyme in the genesis of hypertension.

    AFFILIATION:

    Country: UNITED STATES

    UNITED STATES Research PublicationUNITED STATES Research Publication

    AGENCY:

    GRANT:

    ACRONYM:

    MEDLINETA: Clin Exp Hypertens A

    REFSOURCE:

    DATABASENAME:

    ACCESSION NUMBER:

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