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Pharmacogenomics: challenges and opportunities.

Pharmacogenomics: challenges and opportunities. Research Abstract Details 

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  • Pharmacogenomics: challenges and opportunities. Abstract Text:

    dan m rodenDan M Roden,russ b altmanRuss B Altman,neal l benowitzNeal L Benowitz,david a flockhartDavid A Flockhart,kathleen m giacominiKathleen M Giacomini,julie a johnsonJulie A Johnson,ronald m kraussRonald M Krauss,howard l mcleodHoward L McLeod,mark j ratainMark J Ratain,mary v rellingMary V Relling,huijun z ringHuijun Z Ring,alan r shuldinerAlan R Shuldiner,richard m weinshilboumRichard M Weinshilboum,scott t weissScott T Weiss, ,

    The outcome of drug therapy is often unpredictable, ranging from beneficial effects to lack of efficacy to serious adverse effects. Variations in single genes are 1 well-recognized cause of such unpredictability, defining the field of pharmacogenetics (see Glossary). Such variations may involve genes controlling drug metabolism, drug transport, disease susceptibility, or drug targets. The sequencing of the human genome and the cataloguing of variants across human genomes are the enabling resources for the nascent field of pharmacogenomics (see Glossary), which tests the idea that genomic variability underlies variability in drug responses. However, there are many challenges that must be overcome to apply rapidly accumulating genomic information to understand variable drug responses, including defining candidate genes and pathways; relating disease genes to drug response genes; precisely defining drug response phenotypes; and addressing analytic, ethical, and technological issues involved in generation and management of large drug response data sets. Overcoming these challenges holds the promise of improving new drug development and ultimately individualizing the selection of appropriate drugs and dosages for individual patients.

    Pharmacogenomics: challenges and opportunities. Publishing Authors By Initials

    dm rodenDM Roden,rb altmanRB Altman,nl benowitzNL Benowitz,da flockhartDA Flockhart,km giacominiKM Giacomini,ja johnsonJA Johnson,rm kraussRM Krauss,hl mcleodHL McLeod,mj ratainMJ Ratain,mv rellingMV Relling,hz ringHZ Ring,ar shuldinerAR Shuldiner,rm weinshilboumRM Weinshilboum,st weissST Weiss, ,

    For similar therapeutics: drug therapy: prescriptions, drug research abstracts see: therapeutics: drug therapy: prescriptions, drug research

    PUBMED ID PMID:

    MEDLINE DATE:

    Pharmacogenomics: challenges and opportunities. Journal Published:

    PUBLICATION TYPE: Review

    Journal: Annals of internal medicine

    VOLUME: 145

    Page Numbers: 749-57

    Journal Abbreviation: Ann. Intern. Med.

    ISSN: 1539-3704

    DAY: 21

    MONTH: Nov

    YEAR: 2006

    Pharmacogenomics: challenges and opportunities. Information

    Number of References: 78

    LANGUAGE: eng

    NlmUniqueID: 372351

    Pharmacogenomics: challenges and opportunities. Keywords Mesh Terms:

    KEYWORDS: Prescriptions, Drug

    MESH TERMS: trends

    Chemical & Substance for Abstract: Pharmacogenomics: challenges and opportunities. Information

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    Grant and Affiliation Information for Pharmacogenomics: challenges and opportunities.

    AFFILIATION: Vanderbilt University, Nashville, Tennessee, USA. dan.roden@vanderbilt.edu

    Country: United States

    United States Research PublicationUnited States Research Publication

    AGENCY: United States NHLBI

    GRANT: U01 HL69757

    ACRONYM: HL

    MEDLINETA: Ann Intern Med

    REFSOURCE:

    DATABASENAME:

    ACCESSION NUMBER:

    Number Hits: 0

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