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Novel functions of herbal medicines in dendritic cells: role of amomi semen in tumor immunity.

Novel functions of herbal medicines in dendritic cells: role of amomi semen in tumor immunity. Research Abstract Details 

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  • Novel functions of herbal medicines in dendritic cells: role of amomi semen in tumor immunity. Abstract Text:

    hajime fukuiHajime Fukui,seika mitsuiSeika Mitsui,nobue harimaNobue Harima,mitsuhiko noseMitsuhiko Nose,kunio tsujimuraKunio Tsujimura,hajime mizukamiHajime Mizukami,akimichi moritaAkimichi Morita,hajime fukuiHajime Fukui,seika mitsuiSeika Mitsui,nobue harimaNobue Harima,mitsuhiko noseMitsuhiko Nose,kunio tsujimuraKunio Tsujimura,hajime mizukamiHajime Mizukami,akimichi moritaAkimichi Morita,

    Dendritic cells (DCs) have a major role in regulating immune responses, including tumor immunity and peripheral tolerance. In the present study, we identified novel functions of herbal medicines in DCs by screening 99 herbal medicines, most of which are among the 210 Chinese medicines approved by the Ministry of Health, Labour, and Welfare, Japan. Ethanol extracts were prepared, and a murine epidermal-derived Langerhans cell line, XS106, was used to screen the 99 extracts by analyzing major histocompatibility complex (MHC) class II expression. Amomi Semen (amomum seed), Polyporus (polyporus sclerotium), and Plantaginis Semen (plantago seed) potently activated XS106 and were selected for further analysis. The effects of these extracts on bone marrow-derived DCs (BM-DCs) generated in vitro were then analyzed using surface phenotype (MHC class II, CD80, and CD86) and interleukin (IL)-12p70 production as indicators. BM-DCs treated with Amomi Semen extract exhibited activated phenotypes and secreted IL-12p70. The activation level was similar to that induced by lipopolysaccharides. Finally, an E.G7-OVA tumor model (E.L4-OVA transfectant) was used to examine the anti-tumor effects of Amomi Semen extract. Vaccination of mice with a subcutaneous injection of BM-DCs treated with Amomi Semen extract and OVA peptide significantly inhibited the growth of tumor cells and prolonged survival time compared to controls. Furthermore, therapeutic effects were observed on established tumors. The inhibition rates for both the prophylactic and therapeutic protocols were comparable to those of lipopolysaccharides. These results indicate that Amomi Semen extract potently activate DCs and is potentially useful for DC vaccination.

    Novel functions of herbal medicines in dendritic cells: role of amomi semen in tumor immunity. Publishing Authors By Initials

    h fukuiH Fukui,s mitsuiS Mitsui,n harimaN Harima,m noseM Nose,k tsujimuraK Tsujimura,h mizukamiH Mizukami,a moritaA Morita,h fukuiH Fukui,s mitsuiS Mitsui,n harimaN Harima,m noseM Nose,k tsujimuraK Tsujimura,h mizukamiH Mizukami,a moritaA Morita,

    For similar abstracts research abstracts see: abstracts research

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    Novel functions of herbal medicines in dendritic cells: role of amomi semen in tumor immunity. Journal Published:

    PUBLICATION TYPE: Journal Article

    Journal: Microbiology and immunology

    VOLUME: 51

    Page Numbers: 1121-33

    Journal Abbreviation: Microbiol. Immunol.

    ISSN: 0385-5600

    DAY: 26

    MONTH: 11

    YEAR: 2007

    Novel functions of herbal medicines in dendritic cells: role of amomi semen in tumor immunity. Information

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    LANGUAGE: eng

    NlmUniqueID: 7703966

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    Grant and Affiliation Information for Novel functions of herbal medicines in dendritic cells: role of amomi semen in tumor immunity.

    AFFILIATION: Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences.

    Country: Japan

    Japan Research PublicationJapan Research Publication

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    MEDLINETA: Microbiol Immunol

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