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Neonatal gastric suctioning results in chronic visceral and somatic hyperalgesia: role of corticotropin releasing factor.

Neonatal gastric suctioning results in chronic visceral and somatic hyperalgesia: role of corticotropin releasing factor. Research Abstract Details 

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  • Neonatal gastric suctioning results in chronic visceral and somatic hyperalgesia: role of corticotropin releasing factor. Abstract Text:

    c smithC Smith,e nordstromE Nordstrom,j n senguptaJ N Sengupta,a mirandaA Miranda,

    Abstract Gastric suctioning is common in neonatal intensive care units. Studies suggest that gastric suctioning in premature infants may play a role in the development of visceral hyperalgesia. We hypothesized that repeated orogastric suctioning during the neonatal period results in chronic alterations in visceral and somatic sensation through a corticotropin-releasing factor mediated mechanism. Neonatal male Long Evans rats (n = 13) received daily orogastric suctioning for 10 days starting at postnatal day two (P2). Control rats (n = 15) were handled similarly without orogastric suction. A second study group was subjected to a similar protocol, only with pre-emptive administration of a CRF1 receptor antagonist (antalarmin, 20 mg/kg, IP) (n = 8). The control group received vehicle only (n = 8). An additional group was given antalarmin without suctioning (n = 5). After these rats grew to adulthood (PN 60), a visceromotor response to graded colorectal distension was recorded (10-80 mmHg, 30s, 180s inter-stimulus intervals) to assess changes in visceral sensitivity. Paw withdrawal latency to noxious heat applied to the hind paws was measured to assess changes in cutaneous sensitivity. Orogastric suctioning during the neonatal period results in global chronic somatic and visceral hyperalgesia in adult rats. Visceral hyperalgesia is prevented by pre-emptive administration of the CRF1 receptor antagonist, antalarmin.

    Neonatal gastric suctioning results in chronic visceral and somatic hyperalgesia: role of corticotropin releasing factor. Publishing Authors By Initials

    c smithC Smith,e nordstromE Nordstrom,jn senguptaJN Sengupta,a mirandaA Miranda,

    For similar suction research abstracts see: suction research

    PUBMED ID PMID:

    MEDLINE DATE:

    Neonatal gastric suctioning results in chronic visceral and somatic hyperalgesia: role of corticotropin releasing factor. Journal Published:

    PUBLICATION TYPE: Research Support, Non-U.S. Gov

    Journal: Neurogastroenterology and motility : the official

    VOLUME: 19

    Page Numbers: 692-9

    Journal Abbreviation: Neurogastroenterol. Motil.

    ISSN: 1350-1925

    DAY: 3

    MONTH: Aug

    YEAR: 2007

    Neonatal gastric suctioning results in chronic visceral and somatic hyperalgesia: role of corticotropin releasing factor. Information

    Number of References:

    LANGUAGE: eng

    NlmUniqueID: 9432572

    Neonatal gastric suctioning results in chronic visceral and somatic hyperalgesia: role of corticotropin releasing factor. Keywords Mesh Terms:

    KEYWORDS: Suction

    MESH TERMS: adverse effects

    Chemical & Substance for Abstract: Neonatal gastric suctioning results in chronic visceral and somatic hyperalgesia: role of corticotropin releasing factor. Information

    Substance Name: Corticotropin-Releasing Hormone

    Registry Number: 9015-71-8

    Grant and Affiliation Information for Neonatal gastric suctioning results in chronic visceral and somatic hyperalgesia: role of corticotropin releasing factor.

    AFFILIATION: Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

    Country: England

    England Research Publication

    AGENCY: United States NIDDK

    GRANT: R01 DK 062312-01A2

    ACRONYM: DK

    MEDLINETA: Neurogastroenterol Motil

    REFSOURCE:

    DATABASENAME:

    ACCESSION NUMBER:

    Number Hits: 0

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