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Micturition activity of pollen extract: contractile effects on bladder and inhibitory effects on urethral smooth muscle of mouse and pig.

Micturition activity of pollen extract: contractile effects on bladder and inhibitory effects on urethral smooth muscle of mouse and pig. Research Abstract Details 

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  • Micturition activity of pollen extract: contractile effects on bladder and inhibitory effects on urethral smooth muscle of mouse and pig. Abstract Text:

    m kimuraM Kimura,i kimuraI Kimura,k nakaseK Nakase,t sonobeT Sonobe,n moriN Mori,

    The contractile and inhibitory effects of pollen extracts on bladder and urethral smooth muscle strips from mice and domestic pigs were investigated. In the mice bladder strips, T-60 (a water-soluble extract), GBX (an acetone-soluble extract), and CN (consisting of both T-60 and GBX at a ratio of 20:1) induced contractions at 0.1-3.0 mg/ml in a concentration-dependent manner. CN, T-60, and GBX (3.0 mg/ml) attained 27.6, 27.0, and 7.3% of the ACh response (10.0 microg/ml). The T-60 effect was antagonized noncompetitively by atropine (0.029-0.29 ng/ml). CN, T-60, and GBX inhibited noradrenaline (NA)-contracted urethral strips of mice (IC (50) values for NA 0.3 microg/ml: 0.508, 0.553, and 0.888 mg/ml, and for NA 10.0 microg/ml : 0.556, 0.705, and 0.673 mg/ml). Only GBX relaxed the normal tone of pig urethral strips. The water-soluble extract of corn ( ZEA MAYS) pollen, the main pollen of CN, contracted the mice bladder strips and inhibited NA-contracted urethral strips of mice more potently than T-60. The acetonesoluble extract of corn pollen relaxed the normal tone of the pig urethra and inhibited the NA-contracted mouse urethra more effectively than GBX. These results indicate that by pollen extracts (mainly corn pollen extracts) the urine discharge may be caused by the contractile effect on the bladder, and its inhibitory or relaxing effect on the urethra.

    Micturition activity of pollen extract: contractile effects on bladder and inhibitory effects on urethral smooth muscle of mouse and pig. Publishing Authors By Initials

    m kimuraM Kimura,i kimuraI Kimura,k nakaseK Nakase,t sonobeT Sonobe,n moriN Mori,

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    Micturition activity of pollen extract: contractile effects on bladder and inhibitory effects on urethral smooth muscle of mouse and pig. Journal Published:

    PUBLICATION TYPE: Journal Article

    Journal: Planta medica

    VOLUME: 52

    Page Numbers: 148-51

    Journal Abbreviation: Planta Med.

    ISSN: 0032-0943

    DAY: 8

    MONTH: Apr

    YEAR: 1986

    Micturition activity of pollen extract: contractile effects on bladder and inhibitory effects on urethral smooth muscle of mouse and pig. Information

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    LANGUAGE: eng

    NlmUniqueID: 66751

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    Grant and Affiliation Information for Micturition activity of pollen extract: contractile effects on bladder and inhibitory effects on urethral smooth muscle of mouse and pig.

    AFFILIATION: Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical & Pharmaceutical University, 2630 Sugitani, Toyama 930-01, Japan.

    Country: Germany

    Germany Research PublicationGermany Research Publication

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    MEDLINETA: Planta Med

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