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Isolation of a novel platelet-derived growth factor-responsive precursor from the embryonic ventral forebrain.

Isolation of a novel platelet-derived growth factor-responsive precursor from the embryonic ventral forebrain. Research Abstract Details 

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  • Isolation of a novel platelet-derived growth factor-responsive precursor from the embryonic ventral forebrain. Abstract Text:

    andrew chojnackiAndrew Chojnacki,samuel weissSamuel Weiss,

    Oligodendrocyte progenitor cells express platelet-derived growth factor (PDGF) receptor-alpha and, when expanded in PDGF only, have been shown to generate oligodendrocytes and astrocytes but never neurons. Recent evidence suggests that oligodendrocytes are generated by a common progenitor that also generates neurons but not astrocytes. We used the neurosphere culture system to isolate embryonic ventral forebrain, PDGF-responsive precursors (PRPs). We report that the medial ganglionic eminence is the source of PRP-generated neurospheres and that the progeny can differentiate into parvalbumin-positive interneurons, oligodendrocytes, and astrocytes. Thyroid hormone and bone morphogenetic protein-2 (BMP-2) promote the mutually exclusive differentiation of oligodendrocytes and neurons, respectively, whereas ciliary neurotrophic factor acts with BMP-2 to suppress OLIG2 expression and promote astroglial differentiation. PRPs require fibroblast growth factor-2 together with PDGF to maintain self-renewal, which is dependent on sonic hedgehog signaling. We present evidence for forebrain oligodendrocytes and parvalbumin-positive interneurons being generated by a common precursor and elucidate signals regulating the multiple differentiation routes of the progeny of this precursor.

    Isolation of a novel platelet-derived growth factor-responsive precursor from the embryonic ventral forebrain. Publishing Authors By Initials

    a chojnackiA Chojnacki,s weissS Weiss,

    For similar hormones, hormone substitutes, and hormone antagonists: hormones: thyroid hormones: thyronines: triiodothyronine research abstracts see: hormones, hormone substitutes, and hormone antagonists: hormones: thyroid hormones: thyronines: triiodothyronine research

    PUBMED ID PMID:

    MEDLINE DATE:

    Isolation of a novel platelet-derived growth factor-responsive precursor from the embryonic ventral forebrain. Journal Published:

    PUBLICATION TYPE: Research Support, Non-U.S. Gov

    Journal: The Journal of neuroscience : the official journal

    VOLUME: 24

    Page Numbers: 10888-99

    Journal Abbreviation: J. Neurosci.

    ISSN: 1529-2401

    DAY: 1

    MONTH: Dec

    YEAR: 2004

    Isolation of a novel platelet-derived growth factor-responsive precursor from the embryonic ventral forebrain. Information

    Number of References:

    LANGUAGE: eng

    NlmUniqueID: 8102140

    Isolation of a novel platelet-derived growth factor-responsive precursor from the embryonic ventral forebrain. Keywords Mesh Terms:

    KEYWORDS: Triiodothyronine

    MESH TERMS: pharmacology

    Chemical & Substance for Abstract: Isolation of a novel platelet-derived growth factor-responsive precursor from the embryonic ventral forebrain. Information

    Substance Name: Triiodothyronine

    Registry Number: 6893-02-3

    Grant and Affiliation Information for Isolation of a novel platelet-derived growth factor-responsive precursor from the embryonic ventral forebrain.

    AFFILIATION: Genes and Development Research Group, Department of Cell Biology and Anatomy, University of Calgary, Faculty of Medicine, Calgary, Alberta, T2N 4N1 Canada.

    Country: United States

    United States Research PublicationUnited States Research Publication

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    MEDLINETA: J Neurosci

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