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Isolation and identification of the rearrangement products of diflunisal 1-O-acyl glucuronide.

Isolation and identification of the rearrangement products of diflunisal 1-O-acyl glucuronide. Research Abstract Details 

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  • Isolation and identification of the rearrangement products of diflunisal 1-O-acyl glucuronide. Abstract Text:

    j J ,c cornettC Cornett,l dalgaardL Dalgaard,s h hansenS H Hansen,

    A preparative reversed-phase high-performance liquid chromatographic method is described for the simultaneous separation of eight different isomers formed from the 1-O-acyl glucuronide of diflunisal. All isomers were formed when the acyl glucuronide was incubated under mildly alkaline conditions in aqueous solution. Various forms of two-dimensional NMR studies were performed in order to identify each isomer. Seven of the isomers were identified as alpha- and beta-forms of esters in which diflunisal forms an ester with one of the four alcohol groups in the glucupyranuronic acid. One isomer was identified as the ether glucuronide of diflunisal. To establish the exact chemical shift of the different protons, simulation of the one-dimensional NMR spectra and iterative analyses were performed.

    Isolation and identification of the rearrangement products of diflunisal 1-O-acyl glucuronide. Publishing Authors By Initials

    j J ,c cornettC Cornett,l dalgaardL Dalgaard,sh hansenSH Hansen,

    For similar abstracts research abstracts see: abstracts research

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    Isolation and identification of the rearrangement products of diflunisal 1-O-acyl glucuronide. Journal Published:

    PUBLICATION TYPE: Journal Article

    Journal: Journal of pharmaceutical and biomedical analysis

    VOLUME: 6

    Page Numbers: 229-40

    Journal Abbreviation:

    ISSN: 0731-7085

    DAY: 26

    MONTH: 07

    YEAR: 1988

    Isolation and identification of the rearrangement products of diflunisal 1-O-acyl glucuronide. Information

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    LANGUAGE: eng

    NlmUniqueID: 8309336

    Isolation and identification of the rearrangement products of diflunisal 1-O-acyl glucuronide. Keywords Mesh Terms:

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    Grant and Affiliation Information for Isolation and identification of the rearrangement products of diflunisal 1-O-acyl glucuronide.

    AFFILIATION: Royal Danish School of Pharmacy, Department of Chemistry BC, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

    Country: England

    England Research Publication

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    MEDLINETA: J Pharm Biomed Anal

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