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Introducing genetically encoded aldehydes into proteins.

Introducing genetically encoded aldehydes into proteins. Research Abstract Details 

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  • Introducing genetically encoded aldehydes into proteins. Abstract Text:

    isaac s carricoIsaac S Carrico,brian l carlsonBrian L Carlson,carolyn r bertozziCarolyn R Bertozzi,isaac s carricoIsaac S Carrico,brian l carlsonBrian L Carlson,carolyn r bertozziCarolyn R Bertozzi,isaac s carricoIsaac S Carrico,brian l carlsonBrian L Carlson,carolyn r bertozziCarolyn R Bertozzi,

    Methods for introducing bioorthogonal functionalities into proteins have become central to protein engineering efforts. Here we describe a method for the site-specific introduction of aldehyde groups into recombinant proteins using the 6-amino-acid consensus sequence recognized by the formylglycine-generating enzyme. This genetically encoded 'aldehyde tag' is no larger than a His(6) tag and can be exploited for numerous protein labeling applications.

    Introducing genetically encoded aldehydes into proteins. Publishing Authors By Initials

    is carricoIS Carrico,bl carlsonBL Carlson,cr bertozziCR Bertozzi,is carricoIS Carrico,bl carlsonBL Carlson,cr bertozziCR Bertozzi,is carricoIS Carrico,bl carlsonBL Carlson,cr bertozziCR Bertozzi,

    For similar enzymes and coenzymes: enzymes: hydrolases: esterases: sulfatases research abstracts see: enzymes and coenzymes: enzymes: hydrolases: esterases: sulfatases research

    PUBMED ID PMID:

    MEDLINE DATE:

    Introducing genetically encoded aldehydes into proteins. Journal Published:

    PUBLICATION TYPE: Research Support, U.S. Gov't,

    Journal: Nature chemical biology

    VOLUME: 3

    Page Numbers: 321-2

    Journal Abbreviation: Nat. Chem. Biol.

    ISSN: 1552-4450

    DAY: 22

    MONTH: 04

    YEAR: 2007

    Introducing genetically encoded aldehydes into proteins. Information

    Number of References:

    LANGUAGE: eng

    NlmUniqueID: 101231976

    Introducing genetically encoded aldehydes into proteins. Keywords Mesh Terms:

    KEYWORDS: Sulfatases

    MESH TERMS: metabolism

    Chemical & Substance for Abstract: Introducing genetically encoded aldehydes into proteins. Information

    Substance Name: Sulfatases

    Registry Number: EC 3.1.6.-

    Grant and Affiliation Information for Introducing genetically encoded aldehydes into proteins.

    AFFILIATION: Department of Chemistry, Howard Hughes Medical Institute, B84 Hildebrand Hall, University of California, Berkeley, California 94720, USA.

    Country: United States

    United States Research PublicationUnited States Research Publication

    AGENCY: United States NIGMS

    GRANT: GM59907

    ACRONYM: GM

    MEDLINETA: Nat Chem Biol

    REFSOURCE:

    DATABASENAME:

    ACCESSION NUMBER:

    Number Hits: 0

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