Inflammatory cytokines and systemic-onset juvenile idiopathic arthritis.

Inflammatory cytokines and systemic-onset juvenile idiopathic arthritis. Research Abstract Details 

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Inflammatory cytokines and systemic-onset juvenile idiopathic arthritis. Abstract Text:

Shumpei Yokota,Takako Miyamae,Tomoyuki Imagawa,Naomi Iwata,Shigeki Katakura,Masaaki Mori,

Systemic-onset juvenile idiopathic arthritis (JIA) is a severe and steroid-dependent disease, which sometimes progresses to the fatal disease macrophage activation syndrome. An investigation of inflammatory cytokine levels revealed increases in IL-6 in serum of systemic-onset disease patients. Continuously elevated levels of IL-6 in serum may play a important role in manifesting the clinical symptoms and signs of systemic-onset JIA, including spiking fever, rash, arthritis, and serositis. The characteristic fever spikes parallel IL-6 levels. Long-term exposure to high levels of IL-6 in children results in severe growth impairment, which was strongly suggested by the recent establishment of IL-6 transgenic mice. To avoid disease progression to macrophage activation syndrome and the adverse effects of high-dose corticosteroids, it might be reasonable to inhibit the formation of IL-6/IL-6R complex in order to block the binding to gp130 receptor, a biologically active receptor for IL-6. This review will provide evidence of the relationship between IL-6 homeostasis and systemic-onset JIA, and our recent trials of anti-IL-6R antibody (MRA) for children with acute systemic disease intractable to long-term and high-dose corticosteroid therapy. MRA could be a therapeutic modality for children with systemic-onset JIA intractable to high-dose corticosteroids.

Inflammatory cytokines and systemic-onset juvenile idiopathic arthritis. Publishing Authors By Initials

S Yokota,T Miyamae,T Imagawa,N Iwata,S Katakura,M Mori,

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Inflammatory cytokines and systemic-onset juvenile idiopathic arthritis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Modern rheumatology / the Japan Rheumatism Associa

VOLUME: 14

Page Numbers: 12-7

Journal Abbreviation: Mod Rheumatol

ISSN: 1439-7595

DAY: 9

MONTH: 10

YEAR: 2004

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LANGUAGE: eng

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AFFILIATION: Department of Pediatrics, Yokohama City University School of Medicines, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan, syokota@med.yokohama-cu.ac.jp.

Country: Japan

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MEDLINETA: Mod Rheumatol

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