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Inflammatory cytokines and systemic-onset juvenile idiopathic arthritis.

Inflammatory cytokines and systemic-onset juvenile idiopathic arthritis. Research Abstract Details 

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  • Inflammatory cytokines and systemic-onset juvenile idiopathic arthritis. Abstract Text:

    shumpei yokotaShumpei Yokota,takako miyamaeTakako Miyamae,tomoyuki imagawaTomoyuki Imagawa,naomi iwataNaomi Iwata,shigeki katakuraShigeki Katakura,masaaki moriMasaaki Mori,

    Systemic-onset juvenile idiopathic arthritis (JIA) is a severe and steroid-dependent disease, which sometimes progresses to the fatal disease macrophage activation syndrome. An investigation of inflammatory cytokine levels revealed increases in IL-6 in serum of systemic-onset disease patients. Continuously elevated levels of IL-6 in serum may play a important role in manifesting the clinical symptoms and signs of systemic-onset JIA, including spiking fever, rash, arthritis, and serositis. The characteristic fever spikes parallel IL-6 levels. Long-term exposure to high levels of IL-6 in children results in severe growth impairment, which was strongly suggested by the recent establishment of IL-6 transgenic mice. To avoid disease progression to macrophage activation syndrome and the adverse effects of high-dose corticosteroids, it might be reasonable to inhibit the formation of IL-6/IL-6R complex in order to block the binding to gp130 receptor, a biologically active receptor for IL-6. This review will provide evidence of the relationship between IL-6 homeostasis and systemic-onset JIA, and our recent trials of anti-IL-6R antibody (MRA) for children with acute systemic disease intractable to long-term and high-dose corticosteroid therapy. MRA could be a therapeutic modality for children with systemic-onset JIA intractable to high-dose corticosteroids.

    Inflammatory cytokines and systemic-onset juvenile idiopathic arthritis. Publishing Authors By Initials

    s yokotaS Yokota,t miyamaeT Miyamae,t imagawaT Imagawa,n iwataN Iwata,s katakuraS Katakura,m moriM Mori,

    For similar abstracts research abstracts see: abstracts research

    PUBMED ID PMID:

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    Inflammatory cytokines and systemic-onset juvenile idiopathic arthritis. Journal Published:

    PUBLICATION TYPE: Journal Article

    Journal: Modern rheumatology / the Japan Rheumatism Associa

    VOLUME: 14

    Page Numbers: 12-7

    Journal Abbreviation: Mod Rheumatol

    ISSN: 1439-7595

    DAY: 9

    MONTH: 10

    YEAR: 2004

    Inflammatory cytokines and systemic-onset juvenile idiopathic arthritis. Information

    Number of References:

    LANGUAGE: eng

    NlmUniqueID: 100959226

    Inflammatory cytokines and systemic-onset juvenile idiopathic arthritis. Keywords Mesh Terms:

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    Grant and Affiliation Information for Inflammatory cytokines and systemic-onset juvenile idiopathic arthritis.

    AFFILIATION: Department of Pediatrics, Yokohama City University School of Medicines, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan, syokota@med.yokohama-cu.ac.jp.

    Country: Japan

    Japan Research PublicationJapan Research Publication

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    MEDLINETA: Mod Rheumatol

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