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Identification of a neuron-specific human gene, KIAA1110, that is a guanine nucleotide exchange factor for ARF1.

Identification of a neuron-specific human gene, KIAA1110, that is a guanine nucleotide exchange factor for ARF1. Research Abstract Details 

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  • Identification of a neuron-specific human gene, KIAA1110, that is a guanine nucleotide exchange factor for ARF1. Abstract Text:

    yujiro hattoriYujiro Hattori,shigeki ohtaShigeki Ohta,kenji hamadaKenji Hamada,hisafumi yamada-okabeHisafumi Yamada-Okabe,yonehiro kanemuraYonehiro Kanemura,yumi matsuzakiYumi Matsuzaki,hideyuki okanoHideyuki Okano,yutaka kawakamiYutaka Kawakami,masahiro todaMasahiro Toda,yujiro hattoriYujiro Hattori,shigeki ohtaShigeki Ohta,kenji hamadaKenji Hamada,hisafumi yamada-okabeHisafumi Yamada-Okabe,yonehiro kanemuraYonehiro Kanemura,yumi matsuzakiYumi Matsuzaki,hideyuki okanoHideyuki Okano,yutaka kawakamiYutaka Kawakami,masahiro todaMasahiro Toda,

    To identify neuron-specific genes, we performed gene expression profiling, cDNA microarray and in silico ESTs (expressed sequence tags) analyses. We identified a human neuron-specific gene, KIAA1110 (homologue of rat synArfGEF (Po)), that is a member of the guanine nucleotide exchange factor (GEF) for the ADP-ribosylation factor (ARF). RT-PCR analysis showed that the KIAA1110 gene was expressed specifically in the brain among adult human tissues, whereas no apparent expression was observed in immature neural tissues/cells, such as fetal brain, glioma tissues/cells, and neural stem/precursor cells (NSPCs). The KIAA1110 protein was shown to be expressed in mature neurons but not in undifferentiated NSPCs. Immunohistochemical analysis also showed that KIAA1110 was expressed in neurons of the human adult cerebral cortex. Furthermore, the pull-down assay revealed that KIAA1110 has a GEF activity toward ARF1 that regulates transport along the secretion pathway. These results suggest that KIAA1110 is expressed specifically in mature neurons and may play an important role in the secretion pathway as a GEF for ARF1.

    Identification of a neuron-specific human gene, KIAA1110, that is a guanine nucleotide exchange factor for ARF1. Publishing Authors By Initials

    y hattoriY Hattori,s ohtaS Ohta,k hamadaK Hamada,h yamada-okabeH Yamada-Okabe,y kanemuraY Kanemura,y matsuzakiY Matsuzaki,h okanoH Okano,y kawakamiY Kawakami,m todaM Toda,y hattoriY Hattori,s ohtaS Ohta,k hamadaK Hamada,h yamada-okabeH Yamada-Okabe,y kanemuraY Kanemura,y matsuzakiY Matsuzaki,h okanoH Okano,y kawakamiY Kawakami,m todaM Toda,

    For similar abstracts research abstracts see: abstracts research

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    Identification of a neuron-specific human gene, KIAA1110, that is a guanine nucleotide exchange factor for ARF1. Journal Published:

    PUBLICATION TYPE: Research Support, Non-U.S. Gov

    Journal: Biochemical and biophysical research communication

    VOLUME: 364

    Page Numbers: 737-42

    Journal Abbreviation: Biochem. Biophys. Res. Commun.

    ISSN: 1090-2104

    DAY: 15

    MONTH: 10

    YEAR: 2007

    Identification of a neuron-specific human gene, KIAA1110, that is a guanine nucleotide exchange factor for ARF1. Information

    Number of References:

    LANGUAGE: eng

    NlmUniqueID: 372516

    Identification of a neuron-specific human gene, KIAA1110, that is a guanine nucleotide exchange factor for ARF1. Keywords Mesh Terms:

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    Grant and Affiliation Information for Identification of a neuron-specific human gene, KIAA1110, that is a guanine nucleotide exchange factor for ARF1.

    AFFILIATION: Neuroimmunology Research Group, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

    Country: United States

    United States Research PublicationUnited States Research Publication

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    MEDLINETA: Biochem Biophys Res Commun

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