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Hierarchical assembly of model cell surfaces: synthesis of mucin mimetic polymers and their display on supported bilayers.

Hierarchical assembly of model cell surfaces: synthesis of mucin mimetic polymers and their display on supported bilayers. Research Abstract Details 

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  • Hierarchical assembly of model cell surfaces: synthesis of mucin mimetic polymers and their display on supported bilayers. Abstract Text:

    david rabukaDavid Rabuka,raghuveer parthasarathyRaghuveer Parthasarathy,goo soo leeGoo Soo Lee,xing chenXing Chen,jay t grovesJay T Groves,carolyn r bertozziCarolyn R Bertozzi,

    Molecular level analysis of cell-surface phenomena could benefit from model systems comprising structurally defined components. Here we present the first step toward bottom-up assembly of model cell surfaces-the synthesis of mucin mimetics and their incorporation into artificial membranes. Natural mucins are densely glycosylated O-linked glycoproteins that serve numerous functions on cell surfaces. Their large size and extensive glycosylation makes the synthesis of these biopolymers impractical. We designed synthetically tractable glycosylated polymers that possess rodlike extended conformations similar to natural mucins. The glycosylated polymers were end-functionalized with lipid groups and embedded into supported lipid bilayers where they interact with protein receptors in a structure-dependent manner. Furthermore, their dynamic behavior in synthetic membranes mirrored that of natural biomolecules. This system provides a unique framework with which to study the behavior of mucin-like macromolecules in a controlled, cell surface-mimetic environment.

    Hierarchical assembly of model cell surfaces: synthesis of mucin mimetic polymers and their display on supported bilayers. Publishing Authors By Initials

    d rabukaD Rabuka,r parthasarathyR Parthasarathy,gs leeGS Lee,x chenX Chen,jt grovesJT Groves,cr bertozziCR Bertozzi,

    For similar heterocyclic compounds: heterocyclic compounds, 3-ring: xanthenes research abstracts see: heterocyclic compounds: heterocyclic compounds, 3-ring: xanthenes research

    PUBMED ID PMID:

    MEDLINE DATE:

    Hierarchical assembly of model cell surfaces: synthesis of mucin mimetic polymers and their display on supported bilayers. Journal Published:

    PUBLICATION TYPE: Research Support, U.S. Gov't,

    Journal: Journal of the American Chemical Society

    VOLUME: 129

    Page Numbers: 5462-71

    Journal Abbreviation:

    ISSN: 0002-7863

    DAY: 11

    MONTH: 04

    YEAR: 2007

    Hierarchical assembly of model cell surfaces: synthesis of mucin mimetic polymers and their display on supported bilayers. Information

    Number of References:

    LANGUAGE: eng

    NlmUniqueID: 7503056

    Hierarchical assembly of model cell surfaces: synthesis of mucin mimetic polymers and their display on supported bilayers. Keywords Mesh Terms:

    KEYWORDS: Xanthenes

    MESH TERMS: chemistry

    Chemical & Substance for Abstract: Hierarchical assembly of model cell surfaces: synthesis of mucin mimetic polymers and their display on supported bilayers. Information

    Substance Name: Texas red

    Registry Number: 82354-19-6

    Grant and Affiliation Information for Hierarchical assembly of model cell surfaces: synthesis of mucin mimetic polymers and their display on supported bilayers.

    AFFILIATION: Department of Chemistry, Howard Hughes Medical Institute, University of California, California, USA.

    Country: United States

    United States Research PublicationUnited States Research Publication

    AGENCY: United States NIGMS

    GRANT: GM59907

    ACRONYM: GM

    MEDLINETA: J Am Chem Soc

    REFSOURCE:

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    Number Hits: 0

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