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Hepatocyte antigen as a marker of intestinal metaplasia.

Hepatocyte antigen as a marker of intestinal metaplasia. Research Abstract Details 

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  • Hepatocyte antigen as a marker of intestinal metaplasia. Abstract Text:

    peiguo g chuPeiguo G Chu,zhong jiangZhong Jiang,lawrence m weissLawrence M Weiss,

    Intestinal metaplasia is a histologic hallmark of Barrett's esophagus and chronic gastritis. Intestinal metaplasia may progress to dysplasia or carcinomas without proper treatment. Most cases of intestinal metaplasia are easily recognized on hematoxylin and eosin-stained sections. However, some cases of intestinal metaplasia may be hard to recognize if they lack the characteristic mucin-producing cells and Paneth cells, or if they are small in size. Recently, keratin 7, keratin 20, and MUC2 expression patterns were reported to be useful in confirming the diagnosis of intestinal metaplasia. We studied hepatocyte (Hep) antigen (a hepatocellular antigen mainly expressing in normal and neoplastic hepatic tissues) in 33 cases of Barrett's esophagus (9 cases associated with esophageal adenocarcinoma) and 13 cases of chronic gastritis associated with intestinal metaplasia and gastric adenocarcinoma. Hep monoclonal antibody recognizes intestinal metaplasia in all cases. We also compared expression of Hep with that of keratin 7, keratin 20, and MUC2 in intestinal metaplasia. The specificity and sensitivity of Hep for intestinal metaplasia were higher than that of keratin 7 and keratin 20, or MUC2. We conclude that Hep may be used as a single diagnostic marker for intestinal metaplasia.

    Hepatocyte antigen as a marker of intestinal metaplasia. Publishing Authors By Initials

    pg chuPG Chu,z jiangZ Jiang,lm weissLM Weiss,

    For similar biological factors: biological markers: tumor markers, biological research abstracts see: biological factors: biological markers: tumor markers, biological research

    PUBMED ID PMID:

    MEDLINE DATE:

    Hepatocyte antigen as a marker of intestinal metaplasia. Journal Published:

    PUBLICATION TYPE: Journal Article

    Journal: The American journal of surgical pathology

    VOLUME: 27

    Page Numbers: 952-9

    Journal Abbreviation: Am. J. Surg. Pathol.

    ISSN: 0147-5185

    DAY: 30

    MONTH: Jul

    YEAR: 2003

    Hepatocyte antigen as a marker of intestinal metaplasia. Information

    Number of References:

    LANGUAGE: eng

    NlmUniqueID: 7707904

    Hepatocyte antigen as a marker of intestinal metaplasia. Keywords Mesh Terms:

    KEYWORDS: Tumor Markers, Biological

    MESH TERMS: metabolism

    Chemical & Substance for Abstract: Hepatocyte antigen as a marker of intestinal metaplasia. Information

    Substance Name: Keratins

    Registry Number: 68238-35-7

    Grant and Affiliation Information for Hepatocyte antigen as a marker of intestinal metaplasia.

    AFFILIATION: Department of Pathology, City of Hope National Medical Center, Duarte, California 91010, USA. pchu@coh.org

    Country: United States

    United States Research PublicationUnited States Research Publication

    AGENCY:

    GRANT:

    ACRONYM:

    MEDLINETA: Am J Surg Pathol

    REFSOURCE:

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