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Erbb2 regulates inflammation and proliferation in the skin after ultraviolet irradiation.

Erbb2 regulates inflammation and proliferation in the skin after ultraviolet irradiation. Research Abstract Details 

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  • Erbb2 regulates inflammation and proliferation in the skin after ultraviolet irradiation. Abstract Text:

    justin g madsonJustin G Madson,david t lynchDavid T Lynch,kelsey l tinkumKelsey L Tinkum,sumanth k puttaSumanth K Putta,laura a hansenLaura A Hansen,

    Exposure to ultraviolet (UV) irradiation is the major cause of nonmelanoma skin cancer, the most common form of cancer in the United States. UV irradiation has a variety of effects on the skin associated with carcinogenesis, including DNA damage and effects on signal transduction. The alterations in signaling caused by UV regulate inflammation, cell proliferation, and apoptosis. UV also activates the orphan receptor tyrosine kinase and proto-oncogene Erbb2 (HER2/neu). In this study, we demonstrate that the UV-induced activation of Erbb2 regulates the response of the skin to UV. Inhibition or knockdown of Erbb2 before UV irradiation suppressed cell proliferation, cell survival, and inflammation after UV. In addition, Erbb2 was necessary for the UV-induced expression of numerous proinflammatory genes that are regulated by the transcription factors nuclear factor-kappaB and Comp1, including interleukin-1beta, prostaglandin-endoperoxidase synthase 2 (Cyclooxygenase-2), and multiple chemokines. These results reveal the influence of Erbb2 on the UV response and suggest a role for Erbb2 in UV-induced pathologies such as skin cancer.

    Erbb2 regulates inflammation and proliferation in the skin after ultraviolet irradiation. Publishing Authors By Initials

    jg madsonJG Madson,dt lynchDT Lynch,kl tinkumKL Tinkum,sk puttaSK Putta,la hansenLA Hansen,

    For similar abstracts research abstracts see: abstracts research

    PUBMED ID PMID:

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    Erbb2 regulates inflammation and proliferation in the skin after ultraviolet irradiation. Journal Published:

    PUBLICATION TYPE: Research Support, Non-U.S. Gov

    Journal: The American journal of pathology

    VOLUME: 169

    Page Numbers: 1402-14

    Journal Abbreviation:

    ISSN: 0002-9440

    DAY: 3

    MONTH: Oct

    YEAR: 2006

    Erbb2 regulates inflammation and proliferation in the skin after ultraviolet irradiation. Information

    Number of References:

    LANGUAGE: eng

    NlmUniqueID: 370502

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    Grant and Affiliation Information for Erbb2 regulates inflammation and proliferation in the skin after ultraviolet irradiation.

    AFFILIATION: Department of Biomedical Sciences, School of Medicine, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA.

    Country: United States

    United States Research PublicationUnited States Research Publication

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    MEDLINETA: Am J Pathol

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