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EphB3 receptor and ligand expression in the adult rat brain.

EphB3 receptor and ligand expression in the adult rat brain. Research Abstract Details 

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  • EphB3 receptor and ligand expression in the adult rat brain. Abstract Text:

    christopher a willsonChristopher A Willson,roy d fosterRoy D Foster,stephen m oniferStephen M Onifer,scott r whittemoreScott R Whittemore,jorge d mirandaJorge D Miranda,

    Eph receptors and ligands are two families of proteins that control axonal guidance during development. Their expression was originally thought to be developmentally regulated but recent work has shown that several EphA receptors are expressed postnatally. The EphB3 receptors are expressed during embryonic development in multiple regions of the central nervous system but their potential expression and functional role in the adult brain is unknown. We used in situ hybridization, immunohistochemistry, and receptor affinity probe in situ staining to investigate EphB3 receptors mRNA, protein, and ligand (ephrin-B) expression, respectively, in the adult rat brain. Our results indicate that EphB3 receptor mRNA and protein are constitutively expressed in discrete regions of the adult rat brain including the cerebellum, raphe pallidus, hippocampus, entorhinal cortex, and both motor and sensory cortices. The spatial profile of EphB3 receptors was co-localized to regions of the brain that had a high level of EphB3 receptor binding ligands. Its expression pattern suggests that EphB3 may play a role in the maintenance of mature neuronal connections or re-arrangement of synaptic connections during late stages of development.

    EphB3 receptor and ligand expression in the adult rat brain. Publishing Authors By Initials

    ca willsonCA Willson,rd fosterRD Foster,sm oniferSM Onifer,sr whittemoreSR Whittemore,jd mirandaJD Miranda,

    For similar enzymes and coenzymes: enzymes: transferases: phosphotransferases: phosphotransferases (alcohol group acceptor): protein kinases: protein-tyrosine kinases: receptor protein-tyrosine kinases: receptors, eph family: receptor, ephb3 research abstracts see: enzymes and coenzymes: enzymes: transferases: phosphotransferases: phosphotransferases (alcohol group acceptor): protein kinases: protein-tyrosine kinases: receptor protein-tyrosine kinases: receptors, eph family: receptor, ephb3 research

    PUBMED ID PMID:

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    EphB3 receptor and ligand expression in the adult rat brain. Journal Published:

    PUBLICATION TYPE: Research Support, Non-U.S. Gov

    Journal: Journal of molecular histology

    VOLUME: 37

    Page Numbers: 369-80

    Journal Abbreviation: J. Mol. Histol.

    ISSN: 1567-2379

    DAY: 11

    MONTH: 11

    YEAR: 2006

    EphB3 receptor and ligand expression in the adult rat brain. Information

    Number of References:

    LANGUAGE: eng

    NlmUniqueID: 101193653

    EphB3 receptor and ligand expression in the adult rat brain. Keywords Mesh Terms:

    KEYWORDS: Receptor, EphB3

    MESH TERMS: metabolism

    Chemical & Substance for Abstract: EphB3 receptor and ligand expression in the adult rat brain. Information

    Substance Name: Receptor, EphB3

    Registry Number: EC 2.7.1.112

    Grant and Affiliation Information for EphB3 receptor and ligand expression in the adult rat brain.

    AFFILIATION: Kentucky Spinal Cord Injury Research Center, School of Medicine, University of Louisville, Louisville, KY, USA.

    Country: Netherlands

    Netherlands Research PublicationNetherlands Research Publication

    AGENCY: United States NIGMS

    GRANT: S06 GM 008224

    ACRONYM: GM

    MEDLINETA: J Mol Histol

    REFSOURCE:

    DATABASENAME:

    ACCESSION NUMBER:

    Number Hits: 0

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