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Enhancement of capecitabine efficacy by oxaliplatin in human colorectal and gastric cancer xenografts.

Enhancement of capecitabine efficacy by oxaliplatin in human colorectal and gastric cancer xenografts. Research Abstract Details 

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  • Enhancement of capecitabine efficacy by oxaliplatin in human colorectal and gastric cancer xenografts. Abstract Text:

    noriaki sawadaNoriaki Sawada,kumiko kondohKumiko Kondoh,kazushige moriKazushige Mori,

    We have evaluated the antitumor activity of XELOX (a combination therapy of capecitabine (Xeloda) and oxaliplatin) in human colorectal and gastric cancer xenograft models. In human colorectal cancer model CXF280, antitumor activity of the combination at two-thirds of the maximum tolerated dose (MTD) was superior to that of each monotherapy at MTD. Furthermore, in human colorectal cancer model COL-05-JCK and human gastric cancer xenograft model GXF 97, the combination also showed at least additive antitumor activity. In addition, toxicity was not augmented with the combination therapy in these three models. As demonstrated using ELISA or immunohistochemistry, oxaliplatin in xenograft model tumors up-regulated the level of thymidine phosphorylase (dThdPase), a key enzyme for the metabolism of capecitabine to 5-fluorouracil. These results suggest that oxaliplatin might potentiate the antitumor activity of capecitabine by up-regulating the tumor level of dThdPase. Based on these results, clinical trials of XELOX against colorectal and gastric cancers are warranted.

    Enhancement of capecitabine efficacy by oxaliplatin in human colorectal and gastric cancer xenografts. Publishing Authors By Initials

    n sawadaN Sawada,k kondohK Kondoh,k moriK Mori,

    For similar xenograft model antitumor assays research abstracts see: xenograft model antitumor assays research

    PUBMED ID PMID:

    MEDLINE DATE:

    Enhancement of capecitabine efficacy by oxaliplatin in human colorectal and gastric cancer xenografts. Journal Published:

    PUBLICATION TYPE: Journal Article

    Journal: Oncology reports

    VOLUME: 18

    Page Numbers: 775-8

    Journal Abbreviation: Oncol. Rep.

    ISSN: 1021-335X

    DAY: 19

    MONTH: Oct

    YEAR: 2007

    Enhancement of capecitabine efficacy by oxaliplatin in human colorectal and gastric cancer xenografts. Information

    Number of References:

    LANGUAGE: eng

    NlmUniqueID: 9422756

    Enhancement of capecitabine efficacy by oxaliplatin in human colorectal and gastric cancer xenografts. Keywords Mesh Terms:

    KEYWORDS: Xenograft Model Antitumor Assays

    MESH TERMS: metabolism

    Chemical & Substance for Abstract: Enhancement of capecitabine efficacy by oxaliplatin in human colorectal and gastric cancer xenografts. Information

    Substance Name: Thymidine Phosphorylase

    Registry Number: EC 2.4.2.4

    Grant and Affiliation Information for Enhancement of capecitabine efficacy by oxaliplatin in human colorectal and gastric cancer xenografts.

    AFFILIATION: Product Research Department, Kamakura Research Center, Chugai Pharmaceutical Co., Ltd., Kanagawa 247-8530, Japan. sawadanra@chugai-pharm.co.jp

    Country: Greece

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    ACRONYM:

    MEDLINETA: Oncol Rep

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