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Effect of fructose on the capacity of urea-N synthesis in rats.

Effect of fructose on the capacity of urea-N synthesis in rats. Research Abstract Details 

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  • Effect of fructose on the capacity of urea-N synthesis in rats. Abstract Text:

    j h pedersenJ H Pedersen,d alnorD Alnor,h vilstrupH Vilstrup,b a hansenB A Hansen,

    We studied the effect of fructose on hepatic conversion of amino-N to urea-N as quantified by the Capacity of Urea-N Synthesis (CUNS) determined in rats during alanine loading. There were 2 control groups, one without and one with infusion of somatostatin, in order to control the effects of insulin and glucagon. Somatostatin reduced CUNS from 8.5 +/- 0.5 mumol/(min x 100 g BW) to 6.3 +/- 0.3 mumol/(min x 100 g BW) (mean +/- SEM) (p < 0.01) and reduced glucagon concentrations by 75% (p<0.05). Insulin and glucose concentrations did not change. Fructose, at blood concentrations of about 1 mmol/l further reduced CUNS to 3.6 +/- 0.3 mumol/(min x 100 g BW) (p < 0.01). Insulin increased slightly (p < 0.05), but neither glucose nor glucagon changed. At increasing fructose concentrations up to 2 mmol/l there was no further effect on CUNS. Fructose in concentrations as used for parenteral nutrition and independent of glucoregulatory hormones, decreased hepatic amino acid catabolism.

    Effect of fructose on the capacity of urea-N synthesis in rats. Publishing Authors By Initials

    jh pedersenJH Pedersen,d alnorD Alnor,h vilstrupH Vilstrup,ba hansenBA Hansen,

    For similar abstracts research abstracts see: abstracts research

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    Effect of fructose on the capacity of urea-N synthesis in rats. Journal Published:

    PUBLICATION TYPE: Journal Article

    Journal: Clinical nutrition (Edinburgh, Scotland)

    VOLUME: 13

    Page Numbers: 243-6

    Journal Abbreviation:

    ISSN: 0261-5614

    DAY: 17

    MONTH: Aug

    YEAR: 1994

    Effect of fructose on the capacity of urea-N synthesis in rats. Information

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    LANGUAGE: eng

    NlmUniqueID: 8309603

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    Grant and Affiliation Information for Effect of fructose on the capacity of urea-N synthesis in rats.

    AFFILIATION: Division of Hepatology, Department of Medicine A, Rigshospitalet, Copenhagen, Denmark.

    Country: England

    England Research Publication

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    MEDLINETA: Clin Nutr

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