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Diffusion tensor imaging in children with periventricular leukomalacia: variability of injuries to white matter tracts.

Diffusion tensor imaging in children with periventricular leukomalacia: variability of injuries to white matter tracts. Research Abstract Details 

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  • Diffusion tensor imaging in children with periventricular leukomalacia: variability of injuries to white matter tracts. Abstract Text:

    l m nagaeL M Nagae,a h hoonA H Hoon,e stashinkoE Stashinko,d linD Lin,w zhangW Zhang,e leveyE Levey,s wakanaS Wakana,h jiangH Jiang,c c leiteC C Leite,l t lucatoL T Lucato,p c m van zijlP C M van Zijl,m v johnstonM V Johnston,s moriS Mori,l m nagaeL M Nagae,a h hoonA H Hoon,e stashinkoE Stashinko,d linD Lin,w zhangW Zhang,e leveyE Levey,s wakanaS Wakana,h jiangH Jiang,c c leiteC C Leite,l t lucatoL T Lucato,p c m van zijlP C M van Zijl,m v johnstonM V Johnston,s moriS Mori,

    BACKGROUND AND PURPOSE: Conventional MR imaging shows evidence of brain injury and/or maldevelopment in 70%-90% of children with cerebral palsy (CP), though its capability to identify specific white matter tract injury is limited. The great variability of white matter lesions in CP already demonstrated by postmortem studies is thought to be one of the reasons why response to treatment is so variable. Our hypothesis is that diffusion tensor imaging (DTI) is a suitable technique to provide in vivo characterization of specific white matter tract lesions in children with CP associated with periventricular leukomalacia (PVL). MATERIALS AND METHODS: In this study, 24 children with CP associated with PVL and 35 healthy controls were evaluated with DTI. Criteria for identification of 26 white matter tracts on the basis of 2D DTI color-coded maps were established, and a qualitative scoring system, based on visual inspection of the tracts in comparison with age-matched controls, was used to grade the severity of abnormalities. An ordinal grading system (0=normal, 1=abnormal, 2=severely abnormal or absent) was used to score each white matter tract. RESULTS: There was marked variability in white matter injury pattern in patients with PVL, with the most frequent injury to the retrolenticular part of the internal capsule, posterior thalamic radiation, superior corona radiata, and commissural fibers. CONCLUSION: DTI is a suitable technique for in vivo assessment of specific white matter lesions in patients with PVL and, thus, a potentially valuable diagnostic tool. The tract-specific evaluation revealed a family of tracts that are highly susceptible in PVL, important information that can potentially be used to tailor treatment options in the future.

    Diffusion tensor imaging in children with periventricular leukomalacia: variability of injuries to white matter tracts. Publishing Authors By Initials

    lm nagaeLM Nagae,ah hoonAH Hoon,e stashinkoE Stashinko,d linD Lin,w zhangW Zhang,e leveyE Levey,s wakanaS Wakana,h jiangH Jiang,cc leiteCC Leite,lt lucatoLT Lucato,pc van zijlPC van Zijl,mv johnstonMV Johnston,s moriS Mori,lm nagaeLM Nagae,ah hoonAH Hoon,e stashinkoE Stashinko,d linD Lin,w zhangW Zhang,e leveyE Levey,s wakanaS Wakana,h jiangH Jiang,cc leiteCC Leite,lt lucatoLT Lucato,pc van zijlPC van Zijl,mv johnstonMV Johnston,s moriS Mori,

    For similar investigative techniques: epidemiologic methods: statistics as topic: sensitivity and specificity research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: sensitivity and specificity research

    PUBMED ID PMID:

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    Diffusion tensor imaging in children with periventricular leukomalacia: variability of injuries to white matter tracts. Journal Published:

    PUBLICATION TYPE: Research Support, Non-U.S. Gov

    Journal: AJNR. American journal of neuroradiology

    VOLUME: 28

    Page Numbers: 1213-22

    Journal Abbreviation:

    ISSN: 0195-6108

    DAY: 3

    MONTH: Aug

    YEAR: 2007

    Diffusion tensor imaging in children with periventricular leukomalacia: variability of injuries to white matter tracts. Information

    Number of References:

    LANGUAGE: eng

    NlmUniqueID: 8003708

    Diffusion tensor imaging in children with periventricular leukomalacia: variability of injuries to white matter tracts. Keywords Mesh Terms:

    KEYWORDS: Sensitivity and Specificity

    MESH TERMS: pathology

    Chemical & Substance for Abstract: Diffusion tensor imaging in children with periventricular leukomalacia: variability of injuries to white matter tracts. Information

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    Grant and Affiliation Information for Diffusion tensor imaging in children with periventricular leukomalacia: variability of injuries to white matter tracts.

    AFFILIATION: Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USAand Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Brazil. lidiamayumi@gmail.com

    Country: United States

    United States Research PublicationUnited States Research Publication

    AGENCY: United States NIA

    GRANT: R01 AG20012

    ACRONYM: AG

    MEDLINETA: AJNR Am J Neuroradiol

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