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Comparison of NMDA modulation of breathing and NR1 expression in medullary nuclei of weanling male and female rats.

Comparison of NMDA modulation of breathing and NR1 expression in medullary nuclei of weanling male and female rats. Research Abstract Details 

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  • Comparison of NMDA modulation of breathing and NR1 expression in medullary nuclei of weanling male and female rats. Abstract Text:

    evelyn h schlenkerEvelyn H Schlenker,susan n hansenSusan N Hansen,

    We investigated effects of dextromethophan (DXM), an NMDA receptor antagonist, on ventilation and metabolism in unanesthetized male and female weanling rats, and densities of neurons positive for the NR1 subunit in four medullary nuclei. Relative to saline, DXM treatment decreased oxygen consumption 12% in males and increased it 9% in females (interaction, P<0.05). DXM compared to saline decreased frequency of breathing significantly more in females than males when exposed to hypercapnia. During hypoxia, DXM relative to saline significantly decreased frequency and minute ventilation in males and increased these variables in females. NR1 positive neuron densities were significantly greater in females than males in the nucleus tractus solitarius (NTS), commissural nucleus of the NTS and hypoglossal nucleus due to higher counts. Few sex differences were noted in the dorsal vagal motor nucleus. Thus, in weanling rats NMDA receptor modulation of breathing is sex specific, as are the densities of NR1 positive neurons in medullary nuclei associated with control of breathing.

    Comparison of NMDA modulation of breathing and NR1 expression in medullary nuclei of weanling male and female rats. Publishing Authors By Initials

    eh schlenkerEH Schlenker,sn hansenSN Hansen,

    For similar biochemical phenomena, metabolism, and nutrition: nutrition physiology: child nutrition physiology: infant nutrition physiology: weaning research abstracts see: biochemical phenomena, metabolism, and nutrition: nutrition physiology: child nutrition physiology: infant nutrition physiology: weaning research

    PUBMED ID PMID:

    MEDLINE DATE:

    Comparison of NMDA modulation of breathing and NR1 expression in medullary nuclei of weanling male and female rats. Journal Published:

    PUBLICATION TYPE: Research Support, N.I.H., Extr

    Journal: Respiratory physiology & neurobiology

    VOLUME: 155

    Page Numbers: 203-12

    Journal Abbreviation:

    ISSN: 1569-9048

    DAY: 24

    MONTH: 07

    YEAR: 2006

    Comparison of NMDA modulation of breathing and NR1 expression in medullary nuclei of weanling male and female rats. Information

    Number of References:

    LANGUAGE: eng

    NlmUniqueID: 101140022

    Comparison of NMDA modulation of breathing and NR1 expression in medullary nuclei of weanling male and female rats. Keywords Mesh Terms:

    KEYWORDS: Weaning

    MESH TERMS: physiology

    Chemical & Substance for Abstract: Comparison of NMDA modulation of breathing and NR1 expression in medullary nuclei of weanling male and female rats. Information

    Substance Name: N-Methylaspartate

    Registry Number: 6384-92-5

    Grant and Affiliation Information for Comparison of NMDA modulation of breathing and NR1 expression in medullary nuclei of weanling male and female rats.

    AFFILIATION: Division of Basic Biomedical Sciences, Sanford School of Medicine of the University of South Dakota, 414 East Clark Street, Vermillion, SD 57069, United States. Evelyn.Schlenker@usd.edu <Evelyn.Schlenker@usd.edu>

    Country: Netherlands

    Netherlands Research PublicationNetherlands Research Publication

    AGENCY: United States NCRR

    GRANT: P20 RR15567

    ACRONYM: RR

    MEDLINETA: Respir Physiol Neurobiol

    REFSOURCE:

    DATABASENAME:

    ACCESSION NUMBER:

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