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Chemical synthesis of lymphotactin: a glycosylated chemokine with a C-terminal mucin-like domain.

Chemical synthesis of lymphotactin: a glycosylated chemokine with a C-terminal mucin-like domain. Research Abstract Details 

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  • Chemical synthesis of lymphotactin: a glycosylated chemokine with a C-terminal mucin-like domain. Abstract Text:

    The synthesis of a 93-residue chemokine, lymphotactin, containing eight sites of O-linked glycosylation, was achieved using the technique of native chemical ligation. A single GalNAc residue was incorporated at each glycosylation site using standard Fmoc-chemistry to achieve the first total synthesis of a mucin-type glycoprotein. Using this approach quantities of homogeneous material were obtained for structural and functional analysis.

    Chemical synthesis of lymphotactin: a glycosylated chemokine with a C-terminal mucin-like domain. Publishing Authors By Initials

    For similar sialoglycoproteins research abstracts see: sialoglycoproteins research

    PUBMED ID PMID:

    MEDLINE DATE:

    Chemical synthesis of lymphotactin: a glycosylated chemokine with a C-terminal mucin-like domain. Journal Published:

    PUBLICATION TYPE: Research Support, U.S. Gov't,

    Journal: Chemistry (Weinheim an der Bergstrasse, Germany)

    VOLUME: 7

    Page Numbers: 1129-32

    Journal Abbreviation:

    ISSN: 0947-6539

    DAY: 2

    MONTH: Mar

    YEAR: 2001

    Chemical synthesis of lymphotactin: a glycosylated chemokine with a C-terminal mucin-like domain. Information

    Number of References:

    LANGUAGE: eng

    NlmUniqueID: 9513783

    Chemical synthesis of lymphotactin: a glycosylated chemokine with a C-terminal mucin-like domain. Keywords Mesh Terms:

    KEYWORDS: Sialoglycoproteins

    MESH TERMS: pharmacology

    Chemical & Substance for Abstract: Chemical synthesis of lymphotactin: a glycosylated chemokine with a C-terminal mucin-like domain. Information

    Substance Name: lymphotactin

    Registry Number: 0

    Grant and Affiliation Information for Chemical synthesis of lymphotactin: a glycosylated chemokine with a C-terminal mucin-like domain.

    AFFILIATION: Department of Chemistry, Howard Hughes Medical Institute, University of California, Berkeley 94720, USA.

    Country: Germany

    Germany Research PublicationGermany Research Publication

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    GRANT:

    ACRONYM:

    MEDLINETA: Chemistry

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    Number Hits: 0

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