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BMP-2 inhibits proliferation of human aortic smooth muscle cells via p21Cip1/Waf1.

BMP-2 inhibits proliferation of human aortic smooth muscle cells via p21Cip1/Waf1. Research Abstract Details 

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  • BMP-2 inhibits proliferation of human aortic smooth muscle cells via p21Cip1/Waf1. Abstract Text:

    gail a wongGail A Wong,vincent tangVincent Tang,faten el-sabeawyFaten El-Sabeawy,robert h weissRobert H Weiss,

    Bone-morphogenetic proteins (BMP)-2 and -7, multifunctional members of the transforming growth factor (TGF)-beta superfamily with powerful osteoinductive effects, cause cell cycle arrest in a variety of transformed cell lines by activating signaling cascades that involve several cyclin-dependent kinase inhibitors (CDKIs). CDKIs in the cip/kip family, p21(Cip1/Waf1) and p27(Kip1), have been shown to negatively regulate the G1 cyclins and their partner cyclin-dependent kinase proteins, resulting in BMP-mediated growth arrest. Bone morphogens have also been associated with antiproliferative effects in vascular tissue by unknown mechanisms. We now show that BMP-2-mediated inhibition of platelet-derived growth factor (PDGF)-stimulated human aortic smooth muscle cell (HASMC) proliferation is accompanied by increased levels of p21 protein. Antisense oligodeoxynucleotides specific for p21 attenuate BMP-2-induced inhibition of proliferation when transfected into HASMCs, demonstrating that BMP-2 inhibits PDGF-stimulated proliferation of HASMCs through induction of p21. Whether p21-mediated induction of cell cycle arrest by BMP-2 sets the stage for osteogenic differentiation of vascular smooth muscle cells, ultimately leading to vascular mineralization, remains to be investigated.

    BMP-2 inhibits proliferation of human aortic smooth muscle cells via p21Cip1/Waf1. Publishing Authors By Initials

    ga wongGA Wong,v tangV Tang,f el-sabeawyF El-Sabeawy,rh weissRH Weiss,

    For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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    BMP-2 inhibits proliferation of human aortic smooth muscle cells via p21Cip1/Waf1. Journal Published:

    PUBLICATION TYPE: Research Support, U.S. Gov't,

    Journal: American journal of physiology. Endocrinology and

    VOLUME: 284

    Page Numbers: E972-9

    Journal Abbreviation: Am. J. Physiol. Endocrinol. Me

    ISSN: 0193-1849

    DAY: 14

    MONTH: 01

    YEAR: 2003

    BMP-2 inhibits proliferation of human aortic smooth muscle cells via p21Cip1/Waf1. Information

    Number of References:

    LANGUAGE: eng

    NlmUniqueID: 100901226

    BMP-2 inhibits proliferation of human aortic smooth muscle cells via p21Cip1/Waf1. Keywords Mesh Terms:

    KEYWORDS: Transforming Growth Factor beta

    MESH TERMS: pharmacology

    Chemical & Substance for Abstract: BMP-2 inhibits proliferation of human aortic smooth muscle cells via p21Cip1/Waf1. Information

    Substance Name: bone morphogenetic protein 2

    Registry Number: 0

    Grant and Affiliation Information for BMP-2 inhibits proliferation of human aortic smooth muscle cells via p21Cip1/Waf1.

    AFFILIATION: Department of Internal Medicine, Division of Endocrinology, Clinical Nutrition and Vascular Medicine, University of California-Davis, UC Davis Medical Center, 4150 V Street, PSSB G400, Sacramento, CA 95817, USA. gawong@ucdavis.edu

    Country: United States

    United States Research PublicationUnited States Research Publication

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    MEDLINETA: Am J Physiol Endocrinol Metab

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