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Bacteremic sepsis disturbs alveolar perfusion distribution in the lungs of rats.

Bacteremic sepsis disturbs alveolar perfusion distribution in the lungs of rats. Research Abstract Details 

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  • Bacteremic sepsis disturbs alveolar perfusion distribution in the lungs of rats. Abstract Text:

    robert l conhaimRobert L Conhaim,kal e watsonKal E Watson,carol a spiegelCarol A Spiegel,william f doviWilliam F Dovi,bruce a harmsBruce A Harms,robert l conhaimRobert L Conhaim,kal e watsonKal E Watson,carol a spiegelCarol A Spiegel,william f doviWilliam F Dovi,bruce a harmsBruce A Harms,

    OBJECTIVE:: Sepsis often leads to lung injury, although the mechanisms that initiate this are unclear. One preinjury phenomenon that has not been explored previously is the effect of bacterial (nonlipopolysaccharide) sepsis on the distribution of alveolar perfusion. The goals of our studies were to measure this. DESIGN:: Randomized, controlled, prospective animal study. SETTING:: University animal laboratory. SUBJECTS:: Male Sprague-Dawley rats (450-550 g). INTERVENTIONS:: We induced sepsis by placing gelatin capsules containing Escherichia coli and Bacteroides fragilis into the abdomens of rats (n = 9). Empty capsules (n = 6) were placed into the abdomens of controls. After 24 hrs, 4-mum-diameter fluorescent latex particles (2 x 10) were infused into the pulmonary circulation. Sepsis was induced in additional rats and controls to assess lung injury, as follows: Lung histology was performed on eight septic rats and on seven controls; lung lavage was performed on three septic rats and three controls after their plasma albumin had been labeled with Evans blue dye. MEASUREMENTS AND MAIN RESULTS:: Confocal microscopy was used to prepare digital maps of latex particle trapping patterns (eight per lung). Analysis of these patterns revealed statistically more clustering (perfusion inhomogeneity) down to tissue volumes less than that of ten alveoli in septic lungs compared with controls (p

    Bacteremic sepsis disturbs alveolar perfusion distribution in the lungs of rats. Publishing Authors By Initials

    rl conhaimRL Conhaim,ke watsonKE Watson,ca spiegelCA Spiegel,wf doviWF Dovi,ba harmsBA Harms,rl conhaimRL Conhaim,ke watsonKE Watson,ca spiegelCA Spiegel,wf doviWF Dovi,ba harmsBA Harms,

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    Bacteremic sepsis disturbs alveolar perfusion distribution in the lungs of rats. Journal Published:

    PUBLICATION TYPE: Journal Article

    Journal: Critical care medicine

    VOLUME: 36

    Page Numbers: 511-7

    Journal Abbreviation: Crit. Care Med.

    ISSN: 1530-0293

    DAY: 25

    MONTH: Feb

    YEAR: 2008

    Bacteremic sepsis disturbs alveolar perfusion distribution in the lungs of rats. Information

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    LANGUAGE: eng

    NlmUniqueID: 355501

    Bacteremic sepsis disturbs alveolar perfusion distribution in the lungs of rats. Keywords Mesh Terms:

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    Grant and Affiliation Information for Bacteremic sepsis disturbs alveolar perfusion distribution in the lungs of rats.

    AFFILIATION: From the Departments of Surgery (RLC, KEW, BAH), and Pathology and Laboratory Medicine (CAS), University of Wisconsin Medical School, and the William S. Middleton Memorial Veterans Hospital (RLC, WFD, BAH), Madison, WI.

    Country: United States

    United States Research PublicationUnited States Research Publication

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    MEDLINETA: Crit Care Med

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