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A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells.

A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells. Research Abstract Details 

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  • A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells. Abstract Text:

    jong in yookJong In Yook,xiao-yan liXiao-Yan Li,ichiro otaIchiro Ota,casey huCasey Hu,hyun sil kimHyun Sil Kim,nam hee kimNam Hee Kim,so young chaSo Young Cha,joo kyung ryuJoo Kyung Ryu,yoon jung choiYoon Jung Choi,jin kimJin Kim,eric r fearonEric R Fearon,stephen j weissStephen J Weiss,

    Accumulating evidence indicates that hyperactive Wnt signalling occurs in association with the development and progression of human breast cancer. As a consequence of engaging the canonical Wnt pathway, a beta-catenin-T-cell factor (TCF) transcriptional complex is generated, which has been postulated to trigger the epithelial-mesenchymal transition (EMT) that characterizes the tissue-invasive phenotype. However, the molecular mechanisms by which the beta-catenin-TCF complex induces EMT-like programmes remain undefined. Here, we demonstrate that canonical Wnt signalling engages tumour cell dedifferentiation and tissue-invasive activity through an Axin2-dependent pathway that stabilizes the Snail1 zinc-transcription factor, a key regulator of normal and neoplastic EMT programmes. Axin2 regulates EMT by acting as a nucleocytoplasmic chaperone for GSK3beta, the dominant kinase responsible for controlling Snail1 protein turnover and activity. As dysregulated Wnt signalling marks a diverse array of cancerous tissue types, the identification of a beta-catenin-TCF-regulated Axin2-GSK3beta-Snail1 axis provides new mechanistic insights into cancer-associated EMT programmes.

    A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells. Publishing Authors By Initials

    ji yookJI Yook,xy liXY Li,i otaI Ota,c huC Hu,hs kimHS Kim,nh kimNH Kim,sy chaSY Cha,jk ryuJK Ryu,yj choiYJ Choi,j kimJ Kim,er fearonER Fearon,sj weissSJ Weiss,

    For similar proteins: armadillo domain proteins: beta catenin research abstracts see: proteins: armadillo domain proteins: beta catenin research

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    A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells. Journal Published:

    PUBLICATION TYPE: Research Support, Non-U.S. Gov

    Journal: Nature cell biology

    VOLUME: 8

    Page Numbers: 1398-406

    Journal Abbreviation: Nat. Cell Biol.

    ISSN: 1465-7392

    DAY: 29

    MONTH: 10

    YEAR: 2006

    A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells. Information

    Number of References:

    LANGUAGE: eng

    NlmUniqueID: 100890575

    A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells. Keywords Mesh Terms:

    KEYWORDS: beta Catenin

    MESH TERMS: metabolism

    Chemical & Substance for Abstract: A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells. Information

    Substance Name: glycogen synthase kinase 3 beta

    Registry Number: EC 2.7.1.37

    Grant and Affiliation Information for A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells.

    AFFILIATION: Department of Oral Pathology, Oral Cancer Research Institute, College of Dentistry Yonsei University, Seoul 120-752, Korea.

    Country: England

    England Research Publication

    AGENCY: United States NCI

    GRANT: 5 R01 CA71699

    ACRONYM: CA

    MEDLINETA: Nat Cell Biol

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