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A polymer scaffold for protein oligomerization.

A polymer scaffold for protein oligomerization. Research Abstract Details 

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  • A polymer scaffold for protein oligomerization. Abstract Text:

    byron r griffithByron R Griffith,benjamin l allenBenjamin L Allen,alan c rapraegerAlan C Rapraeger,laura l kiesslingLaura L Kiessling,

    We report the design and synthesis of well-defined polymers for the noncovalent oligomerization of proteins. The reported scaffolds, which were generated by atom-transfer radical polymerization (ATRP), take advantage of the well-characterized interaction between a Ni2+ complex and an oligohistidine sequence (His tag). Thus, our polymers are designed to facilitate the oligomerization of any protein possessing a His tag. We demonstrate that they can oligomerize fibroblast growth factor-8b (FGF-8b) and promote FGF-8b-mediated cell proliferation in the absence of heparin.

    A polymer scaffold for protein oligomerization. Publishing Authors By Initials

    br griffithBR Griffith,bl allenBL Allen,ac rapraegerAC Rapraeger,ll kiesslingLL Kiessling,

    For similar proteins research abstracts see: proteins research

    PUBMED ID PMID:

    MEDLINE DATE:

    A polymer scaffold for protein oligomerization. Journal Published:

    PUBLICATION TYPE: Research Support, U.S. Gov't,

    Journal: Journal of the American Chemical Society

    VOLUME: 126

    Page Numbers: 1608-9

    Journal Abbreviation: J. Am. Chem. Soc.

    ISSN: 0002-7863

    DAY: 18

    MONTH: Feb

    YEAR: 2004

    A polymer scaffold for protein oligomerization. Information

    Number of References:

    LANGUAGE: eng

    NlmUniqueID: 7503056

    A polymer scaffold for protein oligomerization. Keywords Mesh Terms:

    KEYWORDS: Proteins

    MESH TERMS: pharmacology

    Chemical & Substance for Abstract: A polymer scaffold for protein oligomerization. Information

    Substance Name: Nickel

    Registry Number: 7440-02-0

    Grant and Affiliation Information for A polymer scaffold for protein oligomerization.

    AFFILIATION: Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.

    Country: United States

    United States Research PublicationUnited States Research Publication

    AGENCY: United States NIGMS

    GRANT: GM 55984

    ACRONYM: GM

    MEDLINETA: J Am Chem Soc

    REFSOURCE:

    DATABASENAME:

    ACCESSION NUMBER:

    Number Hits: 0

    A polymer scaffold for protein oligomerization Related Publications

     

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