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A new approach to the chemical synthesis of keto-proteins.

A new approach to the chemical synthesis of keto-proteins. Research Abstract Details 

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  • A new approach to the chemical synthesis of keto-proteins. Abstract Text:

    david tumeltyDavid Tumelty,maia carnevaliMaia Carnevali,les p mirandaLes P Miranda,

    To increase the versatility of protein-conjugation, an orthogonal protection strategy is described, which enables the efficient synthesis of keto-proteins bearing a reactive ketone functionality using Boc, Fmoc, and chemical ligation methodologies. A 1,3-dithiolane group was used to protect the ketone function of levulinate- and pyruvate-derivatized peptides during solid-phase synthesis, acidolytic cleavage, and purification. When required, the 1,3-dithiolane group could be cleanly removed using aqueous silver or mercuric solutions to regenerate the reactive keto-protein at ambient temperature. The liberated keto-protein was chemoselectively conjugated in situ to an aminooxy-derivatized monodisperse polymer.

    A new approach to the chemical synthesis of keto-proteins. Publishing Authors By Initials

    d tumeltyD Tumelty,m carnevaliM Carnevali,lp mirandaLP Miranda,

    For similar proteins research abstracts see: proteins research

    PUBMED ID PMID:

    MEDLINE DATE:

    A new approach to the chemical synthesis of keto-proteins. Journal Published:

    PUBLICATION TYPE: Journal Article

    Journal: Journal of the American Chemical Society

    VOLUME: 125

    Page Numbers: 14238-9

    Journal Abbreviation: J. Am. Chem. Soc.

    ISSN: 0002-7863

    DAY: 26

    MONTH: Nov

    YEAR: 2003

    A new approach to the chemical synthesis of keto-proteins. Information

    Number of References:

    LANGUAGE: eng

    NlmUniqueID: 7503056

    A new approach to the chemical synthesis of keto-proteins. Keywords Mesh Terms:

    KEYWORDS: Proteins

    MESH TERMS: chemical synthesis

    Chemical & Substance for Abstract: A new approach to the chemical synthesis of keto-proteins. Information

    Substance Name: Proteins

    Registry Number: 0

    Grant and Affiliation Information for A new approach to the chemical synthesis of keto-proteins.

    AFFILIATION: Gryphon Therapeutics, 600 Gateway Boulevard, South San Francisco, CA 94080, USA.

    Country: United States

    United States Research PublicationUnited States Research Publication

    AGENCY:

    GRANT:

    ACRONYM:

    MEDLINETA: J Am Chem Soc

    REFSOURCE:

    DATABASENAME:

    ACCESSION NUMBER:

    Number Hits: 0

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