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A hydrophilic azacyclooctyne for cu-free click chemistry.

A hydrophilic azacyclooctyne for cu-free click chemistry. Research Abstract Details 

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  • A hydrophilic azacyclooctyne for cu-free click chemistry. Abstract Text:

    Biomolecules labeled with azides can be detected through Cu-free click chemistry with cyclooctyne probes, but their intrinsic hydrophobicity can compromise bioavailability. Here, we report the synthesis and evaluation of a novel azacyclooctyne, 6,7-dimethoxyazacyclooct-4-yne (DIMAC). Generated in nine steps from a glucose analogue, DIMAC reacted with azide-labeled proteins and cells similarly to cyclooctynes. However, its superior polarity and water solubility reduced nonspecific binding, thereby improving the sensitivity of azide detection.

    A hydrophilic azacyclooctyne for cu-free click chemistry. Publishing Authors By Initials

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    A hydrophilic azacyclooctyne for cu-free click chemistry. Journal Published:

    PUBLICATION TYPE: Journal Article

    Journal: Organic letters

    VOLUME: 10

    Page Numbers: 3097-9

    Journal Abbreviation: Org. Lett.

    ISSN: 1523-7060

    DAY: 13

    MONTH: 06

    YEAR: 2008

    A hydrophilic azacyclooctyne for cu-free click chemistry. Information

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    LANGUAGE: eng

    NlmUniqueID: 100890393

    A hydrophilic azacyclooctyne for cu-free click chemistry. Keywords Mesh Terms:

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    Grant and Affiliation Information for A hydrophilic azacyclooctyne for cu-free click chemistry.

    AFFILIATION: crb@berkeley.edu.

    Country: United States

    United States Research PublicationUnited States Research Publication

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    MEDLINETA: Org Lett

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