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A high-throughput assay for O-GlcNAc transferase detects primary sequence preferences in peptide substrates.

A high-throughput assay for O-GlcNAc transferase detects primary sequence preferences in peptide substrates. Research Abstract Details 

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  • A high-throughput assay for O-GlcNAc transferase detects primary sequence preferences in peptide substrates. Abstract Text:

    tanya m leavyTanya M Leavy,carolyn r bertozziCarolyn R Bertozzi,

    O-GlcNAc transferase (OGT) catalyzes the addition of N-acetylglucosamine (O-GlcNAc) onto a diverse array of intracellular proteins. Although hundreds of proteins are known to be modified by O-GlcNAc, a strict amino acid consensus sequence for OGT has not been identified. In this study, we describe the development of a high-throughput assay for OGT and use it to profile the specificity of the enzyme among a panel of peptide substrates.

    A high-throughput assay for O-GlcNAc transferase detects primary sequence preferences in peptide substrates. Publishing Authors By Initials

    tm leavyTM Leavy,cr bertozziCR Bertozzi,

    For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: substrate specificity research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: substrate specificity research

    PUBMED ID PMID:

    MEDLINE DATE:

    A high-throughput assay for O-GlcNAc transferase detects primary sequence preferences in peptide substrates. Journal Published:

    PUBLICATION TYPE: Research Support, N.I.H., Extr

    Journal: Bioorganic & medicinal chemistry letters

    VOLUME: 17

    Page Numbers: 3851-4

    Journal Abbreviation: Bioorg. Med. Chem. Lett.

    ISSN: 0960-894X

    DAY: 10

    MONTH: 05

    YEAR: 2007

    A high-throughput assay for O-GlcNAc transferase detects primary sequence preferences in peptide substrates. Information

    Number of References:

    LANGUAGE: eng

    NlmUniqueID: 9107377

    A high-throughput assay for O-GlcNAc transferase detects primary sequence preferences in peptide substrates. Keywords Mesh Terms:

    KEYWORDS: Substrate Specificity

    MESH TERMS: metabolism

    Chemical & Substance for Abstract: A high-throughput assay for O-GlcNAc transferase detects primary sequence preferences in peptide substrates. Information

    Substance Name: O-GlcNAc transferase

    Registry Number: EC 2.4.1.-

    Grant and Affiliation Information for A high-throughput assay for O-GlcNAc transferase detects primary sequence preferences in peptide substrates.

    AFFILIATION: Department of Chemistry, Howard Hughes Medical Institute, University of California, Berkeley 94720, USA.

    Country: England

    England Research Publication

    AGENCY: United States NIGMS

    GRANT: GM066047

    ACRONYM: GM

    MEDLINETA: Bioorg Med Chem Lett

    REFSOURCE:

    DATABASENAME:

    ACCESSION NUMBER:

    Number Hits: 0

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