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A calcium-receptor agonist induces gustatory neural responses in bullfrogs.

A calcium-receptor agonist induces gustatory neural responses in bullfrogs. Research Abstract Details 

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  • A calcium-receptor agonist induces gustatory neural responses in bullfrogs. Abstract Text:

    yukio okadaYukio Okada,kotapola g imendraKotapola G Imendra,toshihiro miyazakiToshihiro Miyazaki,hitoshi hotokezakaHitoshi Hotokezaka,rie fujiyamaRie Fujiyama,jorge l zeredoJorge L Zeredo,kazuo todaKazuo Toda,yukio okadaYukio Okada,kotapola g imendraKotapola G Imendra,toshihiro miyazakiToshihiro Miyazaki,hitoshi hotokezakaHitoshi Hotokezaka,rie fujiyamaRie Fujiyama,jorge l zeredoJorge L Zeredo,kazuo todaKazuo Toda,

    The effect of calcium-sensing receptor (CaR) agonists on frog gustatory responses was studied using glossopharyngeal nerve recording and whole-cell patch-clamp recording of isolated taste disc cells. Calcimimetic NPS R-467 dissolved in normal saline solution elicited a large transient response in the nerve. The less active enantiomer of the compound, NPS S-467 induced only a small neural response. The EC(50) for NPS R-467 was about 20 microM. Cross-adaptation experiments were performed to examine the effect of 30 microM NPS R-467 and 100 microM quinine on the gustatory neural response. The magnitude of the R-467-induced response after adaptation to quinine was approximately equal to that after adaptation to normal saline solution, indicating that the receptor site for NPS R-467 is different from the site for quinine. NPS R-467 (100 microM) also induced an inward current accompanied with conductance increase and large depolarization in two (13%) of 15 rod cells, and a sustained decrease in outward current and small depolarization in six (40%) other rod cells. NPS S-467 (100 microM) induced a sustained decrease in outward current and depolarization in five (50%) of 10 rod cells. Another calcimimetic cinacalcet (100 microM) induced an inward current accompanied with conductance increase in three (27%) of 11 rod cells. The results suggest that NPS R-467 induces neural responses through cell responses unrelated to a resting K(+) conductance decrease.

    A calcium-receptor agonist induces gustatory neural responses in bullfrogs. Publishing Authors By Initials

    y okadaY Okada,kg imendraKG Imendra,t miyazakiT Miyazaki,h hotokezakaH Hotokezaka,r fujiyamaR Fujiyama,jl zeredoJL Zeredo,k todaK Toda,y okadaY Okada,kg imendraKG Imendra,t miyazakiT Miyazaki,h hotokezakaH Hotokezaka,r fujiyamaR Fujiyama,jl zeredoJL Zeredo,k todaK Toda,

    For similar abstracts research abstracts see: abstracts research

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    A calcium-receptor agonist induces gustatory neural responses in bullfrogs. Journal Published:

    PUBLICATION TYPE: Research Support, Non-U.S. Gov

    Journal: Cellular and molecular neurobiology

    VOLUME: 27

    Page Numbers: 771-81

    Journal Abbreviation: Cell. Mol. Neurobiol.

    ISSN: 0272-4340

    DAY: 17

    MONTH: 07

    YEAR: 2007

    A calcium-receptor agonist induces gustatory neural responses in bullfrogs. Information

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    LANGUAGE: eng

    NlmUniqueID: 8200709

    A calcium-receptor agonist induces gustatory neural responses in bullfrogs. Keywords Mesh Terms:

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    Grant and Affiliation Information for A calcium-receptor agonist induces gustatory neural responses in bullfrogs.

    AFFILIATION: Integrative Sensory Physiology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki, Nagasaki 852-8588, Japan. okada@nagasaki-u.ac.jp

    Country: United States

    United States Research PublicationUnited States Research Publication

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    MEDLINETA: Cell Mol Neurobiol

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